Analysis of Serum MicroRNAs as Potential Biomarker in Coronary Bifurcation Lesion
Joint Authors
Zhang, Junjie
Liu, Yan
Chen, Shaoliang
Shan, Shoujie
Chen, Liang
Wang, Rong
Kan, Jing
Xu, Tian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Recent evidence suggests that cell-derived circulating miRNAs may serve as the biomarkers of cardiovascular diseases.
However, no study has investigated the potential of circulating miRNAs as biomarker for coronary bifurcation lesion.
In this study, we aimed to characterize the miRNA profiles that could distinguish coronary bifurcation lesion and identify potential miRNAs as biomarkers of coronary bifurcation lesion.
We employed miRNA microarray to screen serum miRNAs profiles of patients with coronary bifurcation lesion and coronary nonbifurcation lesions.
We identified 197 miRNAs differentially expressed, including 150 miRNAs upregulated and 47 miRNAs downregulated.
We chose 3 miRNAs with significant differences for further testing in 200 patients.
RT-PCR analysis of serum samples confirmed that miR30d was upregulated and miR1246 was downregulated in the serum of coronary bifurcation lesion patients compared with nonbifurcation lesion patients.
Our findings suggest that these miRNAs may have a role in the pathogenesis of coronary bifurcation lesion and may represent novel biomarkers for the diagnosis and prognosis of coronary bifurcation lesion.
American Psychological Association (APA)
Liu, Yan& Chen, Shaoliang& Zhang, Junjie& Shan, Shoujie& Chen, Liang& Wang, Rong…[et al.]. 2015. Analysis of Serum MicroRNAs as Potential Biomarker in Coronary Bifurcation Lesion. Disease Markers،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060914
Modern Language Association (MLA)
Liu, Yan…[et al.]. Analysis of Serum MicroRNAs as Potential Biomarker in Coronary Bifurcation Lesion. Disease Markers No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1060914
American Medical Association (AMA)
Liu, Yan& Chen, Shaoliang& Zhang, Junjie& Shan, Shoujie& Chen, Liang& Wang, Rong…[et al.]. Analysis of Serum MicroRNAs as Potential Biomarker in Coronary Bifurcation Lesion. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1060914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060914