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Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review
Joint Authors
Dai, Jun
Yang, Lili
Wang, Jinyu
Xiao, Ying
Ruan, Qiurong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Forkhead box M1 (FOXM1), a member of the Fox transcription factors family, was closely related with cell cycle.
FOXM1 played an important role in MST and prompted a poor prognosis for MST patients.
However, there were also some studies revealing no significant association between the FOXM1 expression and prognosis of patients.
Therefore, we conducted meta-analysis to investigate whether the expression of FOXM1 was associated with MST prognosis.
We collected 36 relevant studies through PubMed database and obtained research data of 4946 patients.
Stata 12.0 was used to express the results as hazard ratio (HR) for time-to-event outcomes with 95% confidence intervals (95% CI).
It was shown that overexpression of FOXM1 was relevant to worse survival of MST patients (HR = 1.99, 95% CI = 1.79–2.21, P<0.001; I2=26.4%, Ph=0.076).
Subgroup analysis suggested that overexpression of FOXM1 in breast cancer (BC), gastric cancer (GC), hepatocellular carcinoma (HCC), pancreatic ductal adenocarcinoma (PDA), and non-small-cell lung cancer (NSCLC) all predicted a worse survival (P<0.05), in addition to ovarian cancer (OC) (P=0.084).
In conclusion, our research indicated that overexpression of FOXM1 was to the disadvantage of the prognosis for majority of MST and therefore can be used as an evaluation index of prognosis.
American Psychological Association (APA)
Dai, Jun& Yang, Lili& Wang, Jinyu& Xiao, Ying& Ruan, Qiurong. 2015. Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review. Disease Markers،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060916
Modern Language Association (MLA)
Dai, Jun…[et al.]. Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review. Disease Markers No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1060916
American Medical Association (AMA)
Dai, Jun& Yang, Lili& Wang, Jinyu& Xiao, Ying& Ruan, Qiurong. Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060916