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Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer
Joint Authors
Moran-Moguel, Maria Cristina
Sanchez-Corona, Jose
Davalos-Rodriguez, Ingrid Patricia
Cruz Quevedo, Edhit Guadalupe
Mimendi Aguilar, Gabriela Monserrat
Juárez Aguilar, Luis Anselmo
Gutierrez Rubio, Susan Andrea
Torres Morán, Martha Isabel
Rosales Gómez, Roberto Carlos
Flores-Martínez, S. E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aims.
KiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines.
Along the KiSS-1 gene at least 294 SNPs have been described; however the association of these polymorphisms as genetic markers for metastasis in breast cancer studies has not been investigated.
Here we describe two simple PCR-RFLPs protocols to identify the rs5780218 (9DelT) and the rs12998 (E20K) KiSS1 polymorphisms and the allelic, genotypic, and haplotypic frequencies in Mexican general population (GP) and patients with benign breast disease (BBD) or breast cancer (BC).
Results.
The rs5780218 polymorphism was individually associated with breast cancer (P=0.0332) and the rs12998 polymorphism shows statistically significant differences when GP versus case (BC and BBD) groups were compared (P<0.0001).
The H1 Haplotype (G/-) occurred more frequently in BC group (0.4256) whereas H2 haplotype (G/T) was the most prevalent in BBD group (0.4674).
Conclusions.
Our data indicated that the rs5780218 polymorphism individually confers susceptibility for development of breast cancer in Mexican population and a possible role as a genetic marker in breast cancer metastasis for H1 haplotype (Wt/variant) in KiSS1 gene must be analyzed in other populations.
American Psychological Association (APA)
Cruz Quevedo, Edhit Guadalupe& Mimendi Aguilar, Gabriela Monserrat& Juárez Aguilar, Luis Anselmo& Gutierrez Rubio, Susan Andrea& Flores-Martínez, S. E.& Davalos-Rodriguez, Ingrid Patricia…[et al.]. 2015. Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060921
Modern Language Association (MLA)
Cruz Quevedo, Edhit Guadalupe…[et al.]. Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060921
American Medical Association (AMA)
Cruz Quevedo, Edhit Guadalupe& Mimendi Aguilar, Gabriela Monserrat& Juárez Aguilar, Luis Anselmo& Gutierrez Rubio, Susan Andrea& Flores-Martínez, S. E.& Davalos-Rodriguez, Ingrid Patricia…[et al.]. Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060921