![](/images/graphics-bg.png)
Clinical Implications and Prognostic Values of Prostate Cancer Susceptibility Candidate Methylation in Primary Nonmuscle Invasive Bladder Cancer
Joint Authors
Kim, Wun-Jae
Kim, Young-Won
Yoon, Hyung-Yoon
Seo, Sung Pil
Lee, Sang Keun
Kang, Ho Won
Kim, Won Tae
Bang, Heui Je
Ryu, Dong Hee
Yun, Seok-Joong
Lee, Sang-Cheol
Kim, Yong-June
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
DNA methylation is the most common and well-characterized epigenetic change in human cancer.
Recently, an association between prostate cancer susceptibility candidate (PRAC) methylation and genitourinary cancer was proposed.
The aim of the present study was to evaluate the association between PRAC methylation status and clinicopathological parameters and prognosis in long-term follow-up primary nonmuscle invasive bladder cancer (NMIBC).
The clinical relevance of PRAC methylation was determined in 136 human bladder specimens (eight normal controls [NCs] and 128 primary NMIBCs) using quantitative pyrosequencing analysis.
PRAC methylation was significantly higher in NMIBC patients than in NCs and was significantly associated with higher grade and more advanced stage of cancer.
Kaplan-Meier estimates revealed significant difference in tumor recurrence and progression according to PRAC methylation status (both p < 0.05).
Multivariate Cox regression analysis revealed that the PRAC methylation status was a strong predictor of recurrence (hazard ratio [HR], 2.652; p = 0.012) and progression (HR, 9.531; p = 0.035) of NMIBC.
Enhanced methylation status of PRAC was positively associated with a high rate of recurrence and progression in NMIBC patients, suggesting that PRAC methylation may be a promising prognostic marker of NMIBC.
American Psychological Association (APA)
Kim, Young-Won& Yoon, Hyung-Yoon& Seo, Sung Pil& Lee, Sang Keun& Kang, Ho Won& Kim, Won Tae…[et al.]. 2015. Clinical Implications and Prognostic Values of Prostate Cancer Susceptibility Candidate Methylation in Primary Nonmuscle Invasive Bladder Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060935
Modern Language Association (MLA)
Kim, Young-Won…[et al.]. Clinical Implications and Prognostic Values of Prostate Cancer Susceptibility Candidate Methylation in Primary Nonmuscle Invasive Bladder Cancer. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060935
American Medical Association (AMA)
Kim, Young-Won& Yoon, Hyung-Yoon& Seo, Sung Pil& Lee, Sang Keun& Kang, Ho Won& Kim, Won Tae…[et al.]. Clinical Implications and Prognostic Values of Prostate Cancer Susceptibility Candidate Methylation in Primary Nonmuscle Invasive Bladder Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060935