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Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease
Joint Authors
Ziaee, Vahid
Assari, Raheleh
Mirmohammadsadeghi, Arash
Moradinejad, Mohammad Hassan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To compare the laboratory data and changes in these data between patients with MAS and patients with flare-up of the autoimmune diseases.
Methods.
In a prospective study, the static laboratory data and dynamic changes in the selected data in 17 consecutive patients with MAS and 53 patients with active disease of SJIA, PJIA, Kawasaki disease, and SLE were compared.
The ROC curve analysis was used to evaluate cut-off points, sensitivity, and specificity of the static and dynamic laboratory data to differentiate between MAS and active disease.
Results.
In the MAS group, the mean CRP3, ALT, AST, total bilirubin, ferritin, LDH, PT, PTT, and INR were significantly higher and the mean WBC2, PMN2, Lymph2, Hgb1, 2, 3, ESR2, serum albumin, and sodium were significantly lower than in control group.
Some of the important cut-off points were PLT2 < 209000/microliter, AST > 38.5, ALT > 38, WBC < 8200 × 103/UL, ferritin > 5277 ng/mL.
Conclusion.
The dynamic changes in some laboratory data, especially PLT, can differentiate between MAS and active disease.
The changes in WBC, PMN, and ESR and the levels of the liver enzymes may also be helpful in the early differentiation.
Very high levels of ferritin may also help the diagnosis along with other clinical and laboratory signs.
American Psychological Association (APA)
Assari, Raheleh& Ziaee, Vahid& Mirmohammadsadeghi, Arash& Moradinejad, Mohammad Hassan. 2015. Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060939
Modern Language Association (MLA)
Assari, Raheleh…[et al.]. Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060939
American Medical Association (AMA)
Assari, Raheleh& Ziaee, Vahid& Mirmohammadsadeghi, Arash& Moradinejad, Mohammad Hassan. Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060939