Antibodies against C1q Are a Valuable Serological Marker for Identification of Systemic Lupus Erythematosus Patients with Active Lupus Nephritis
Joint Authors
Liu, Xiaoming
Chi, Shuhong
Yu, Yunxia
Shi, Juan
Zhang, Yurong
Yang, Jijuan
Yang, Lijuan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
An early diagnosis of lupus nephritis (LN) has an important clinical implication in guiding treatments of systemic lupus erythematosus (SLE) in clinical settings.
In this study, the diagnostic values of circulating autoantibodies to C1q alone or in combination with other markers for accessing active SLE and LN were evaluated.
Methods.
The diagnostic value of anti-C1q autoantibodies for identification of patients with active SLE disease and LN was evaluated by analyzing the level of anti-C1q antibodies in sera from 95 SLE patients, 40 non-SLE patients, and 34 healthy cohorts.
Results.
The prevalence of anti-C1q antibodies was significantly higher in patients with SLE (50/95, 52.6%), active SLE (40/51, 78.4%), and LN (30/35, 85.7%) in comparison with non-SLE patient controls, patients with inactive SLE, and non-LN, respectively.
A combination of anti-C1q with anti-dsDNA and/or levels of complements C3 and C4 exhibited an increased specificity but a decreased sensitivity for identification of patients with active SLE and LN diseases relative to each of these markers alone.
Conclusion.
Anti-C1q antibodies were strongly associated with disease activity and LN in SLE patients, suggesting that it may be a reliable serological marker for identification of SLE patients with active LN and active SLE disease.
American Psychological Association (APA)
Chi, Shuhong& Yu, Yunxia& Shi, Juan& Zhang, Yurong& Yang, Jijuan& Yang, Lijuan…[et al.]. 2015. Antibodies against C1q Are a Valuable Serological Marker for Identification of Systemic Lupus Erythematosus Patients with Active Lupus Nephritis. Disease Markers،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060947
Modern Language Association (MLA)
Chi, Shuhong…[et al.]. Antibodies against C1q Are a Valuable Serological Marker for Identification of Systemic Lupus Erythematosus Patients with Active Lupus Nephritis. Disease Markers No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1060947
American Medical Association (AMA)
Chi, Shuhong& Yu, Yunxia& Shi, Juan& Zhang, Yurong& Yang, Jijuan& Yang, Lijuan…[et al.]. Antibodies against C1q Are a Valuable Serological Marker for Identification of Systemic Lupus Erythematosus Patients with Active Lupus Nephritis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060947