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The -844 G>A PAI-1 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population
Joint Authors
Padilla-Gutiérrez, Jorge Ramón
Flores-Salinas, Hector Enrique
Valle, Yeminia
García-González, Ilian Janet
Valdés-Alvarado, Emmanuel
Sandoval-Pinto, Elena
Valdez-Haro, Angélica
Figuera-Villanueva, Luis Eduardo
Muñoz-Valle, José Francisco
Dávalos-Rodríguez, Nory Omayra
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Acute coronary syndrome (ACS) has an important impact in public health with high morbidity and mortality.
Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease.
Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of the fibrinolysis and also is part of immune response.
The -844 G>A gene polymorphism is related to increased PAI-1 protein levels.
The aim of the study is to evaluate the association of -844 G>A PAI-1 polymorphism with ACS.
Methods.
A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 patients with diagnosis of ACS.
Results.
The most important risk factor in our population was hypertension, followed by smoking.
The genetic distribution showed an association of the A allele ( OR = 1.27 , P = 0.04 ) and AA genotype ( OR = 1.86 , P = 0.02 ) with ACS.
The recessive model displayed similar results ( OR = 1.76 , P = 0.02 ).
As additional finding, we observed significant differences in the genetic distribution of ACS dyslipidemic patients ( OR = 1.99 , P = 0.04 ).
The A allele and AA genotype of -844 polymorphism of PAI-1 gene are risk factors for ACS.
The AA genotype might be associated with the development of dyslipidemia in ACS patients.
American Psychological Association (APA)
García-González, Ilian Janet& Valle, Yeminia& Sandoval-Pinto, Elena& Valdés-Alvarado, Emmanuel& Valdez-Haro, Angélica& Muñoz-Valle, José Francisco…[et al.]. 2015. The -844 G>A PAI-1 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060949
Modern Language Association (MLA)
García-González, Ilian Janet…[et al.]. The -844 G>A PAI-1 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1060949
American Medical Association (AMA)
García-González, Ilian Janet& Valle, Yeminia& Sandoval-Pinto, Elena& Valdés-Alvarado, Emmanuel& Valdez-Haro, Angélica& Muñoz-Valle, José Francisco…[et al.]. The -844 G>A PAI-1 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1060949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060949