Association between Plasma Fibrinogen Levels and Mortality in Acute-on-Chronic Hepatitis B Liver Failure
Joint Authors
Shao, Zhexin
Zhao, Ying
Feng, Limin
Feng, Guofang
Zhang, Juanwen
Zhang, Jie
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Acute-on-chronic liver failure (AoCLF) is the most common type of liver failure and is associated with high mortality.
Fibrinogen is critical in maintaining primary and secondary hemostasis.
Therefore, we prospectively analyzed the association between fibrinogen and outcomes in AoCLF patients.
Plasma fibrinogen was measured in 169 AoCLF, 173 chronic hepatitis B (CHB), and 171 healthy patients using a coagulation method.
The predictive ability of fibrinogen for 3-month mortality in AoCLF patients was assessed using receiver operating characteristic (ROC) curve and multivariable logistic regression analyses.
Plasma fibrinogen was significantly lower in nonsurvivor AoCLF patients compared with survivor AoCLF, CHB, and control patients.
The sensitivity, specificity, and area under the ROC curve of 1/fibrinogen predicting mortality in AoCLF patients were 66.7%, 72.5%, and 0.746 (95% confidence interval (CI): 0.672–0.820, P < 0.001 ), and the fibrinogen cutoff value was 0.90 g/L.
On multivariate logistic regression analysis, low fibrinogen was an independent factor predicting mortality (odds ratio: 0.304; 95% CI: 0.094–0.983; P = 0.047 ).
Nonsurvivor AoCLF patients had significantly decreased fibrinogen levels, suggesting that low plasma fibrinogen may be a useful predictor of poor prognosis in AoCLF patients.
American Psychological Association (APA)
Shao, Zhexin& Zhao, Ying& Feng, Limin& Feng, Guofang& Zhang, Juanwen& Zhang, Jie. 2015. Association between Plasma Fibrinogen Levels and Mortality in Acute-on-Chronic Hepatitis B Liver Failure. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060952
Modern Language Association (MLA)
Shao, Zhexin…[et al.]. Association between Plasma Fibrinogen Levels and Mortality in Acute-on-Chronic Hepatitis B Liver Failure. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060952
American Medical Association (AMA)
Shao, Zhexin& Zhao, Ying& Feng, Limin& Feng, Guofang& Zhang, Juanwen& Zhang, Jie. Association between Plasma Fibrinogen Levels and Mortality in Acute-on-Chronic Hepatitis B Liver Failure. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060952