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Hemostatic Parameters according to Renal Function and Time after Transplantation in Brazilian Renal Transplanted Patients
Joint Authors
Mota, Ana Paula Lucas
Alpoim, Patrícia Nessralla
Figueiredo, Roberta Carvalho de
Dusse, Luci Maria SantAna
Braga Gomes, Karina
Simões e Silva, Ana Cristina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Kidney transplantation is the key for patients with end-stage renal disease, improving quality of life and longer survival.
However, kidney transplant triggers an intense inflammatory response and alters the hemostatic system, but the pathophysiological mechanisms of these changes are not completely understood.
The aim of this cross-sectional cohort study was to investigate hemostatic biomarkers in Brazilian renal transplanted patients according to renal function and time after transplantation.
A total of 159 renal transplanted patients were enrolled and D-Dimer (D-Di), Thrombomodulin (TM), von Willebrand Factor (VWF), and ADAMTS13 plasma levels were assessed by ELISA.
An increase of D-Di was observed in patients with higher levels of creatinine.
ADAMTS13 levels were associated with creatinine plasma levels and D-Di levels with Glomerular Filtration Rate.
These results suggested that D-Di and ADAMTS13 can be promising markers to estimate renal function.
ADAMTS13 should be investigated throughout the posttransplant time to clarify the participation of this enzyme in glomerular filtration and acceptance or rejection of the graft in Brazilian transplanted patients.
American Psychological Association (APA)
Mota, Ana Paula Lucas& Alpoim, Patrícia Nessralla& Figueiredo, Roberta Carvalho de& Simões e Silva, Ana Cristina& Braga Gomes, Karina& Dusse, Luci Maria SantAna. 2015. Hemostatic Parameters according to Renal Function and Time after Transplantation in Brazilian Renal Transplanted Patients. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060956
Modern Language Association (MLA)
Mota, Ana Paula Lucas…[et al.]. Hemostatic Parameters according to Renal Function and Time after Transplantation in Brazilian Renal Transplanted Patients. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1060956
American Medical Association (AMA)
Mota, Ana Paula Lucas& Alpoim, Patrícia Nessralla& Figueiredo, Roberta Carvalho de& Simões e Silva, Ana Cristina& Braga Gomes, Karina& Dusse, Luci Maria SantAna. Hemostatic Parameters according to Renal Function and Time after Transplantation in Brazilian Renal Transplanted Patients. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1060956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060956