Prognostic Value of MicroRNA-182 in Cancers: A Meta-Analysis
Joint Authors
Wang, Fei
Zhong, Shanliang
Zhang, Haijun
Zhang, Wei
Zhang, Hongming
Wu, Xue
Chen, Baoan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
MicroRNA-182 (miR-182) exhibits altered expression in various cancers.
The aim of this study was to investigate the predictive value of miR-182 expression for cancer patient survival.
Methods.
Eligible studies were identified through multiple search strategies, and the hazard ratios (HRs) for patient outcomes were extracted and estimated.
A meta-analysis was performed to evaluate the prognostic value of miR-182.
Results.
In total, 14 studies were included.
A high miR-182 expression level predicted a worse outcome with a pooled HR of 2.18 (95% CI: 1.53–3.11) in ten studies related to overall survival (OS), especially in Chinese populations.
The results of seven studies evaluating disease-free survival/relapse-free survival/recurrence-free interval/disease-specific survival (DFS/RFS/RFI/DSS) produced a pooled HR of 1.77 (95% CI: 0.91–3.43), which was not statistically significant; however, the trend was positive.
When disregarding the DSS from one study, the expression of miR-182 was significantly correlated with DFS/RFS/RFI (pooled HR = 2.52, 95% CI: 1.67–3.79).
Conclusions.
High miR-182 expression is associated with poor OS and DFS/RFS/RFI in some types of cancers, and miR-182 may be a useful prognostic biomarker for predicting cancer prognosis.
However, given the current insufficient relevant data, further clinical studies are needed.
American Psychological Association (APA)
Wang, Fei& Zhong, Shanliang& Zhang, Haijun& Zhang, Wei& Zhang, Hongming& Wu, Xue…[et al.]. 2015. Prognostic Value of MicroRNA-182 in Cancers: A Meta-Analysis. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060960
Modern Language Association (MLA)
Wang, Fei…[et al.]. Prognostic Value of MicroRNA-182 in Cancers: A Meta-Analysis. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060960
American Medical Association (AMA)
Wang, Fei& Zhong, Shanliang& Zhang, Haijun& Zhang, Wei& Zhang, Hongming& Wu, Xue…[et al.]. Prognostic Value of MicroRNA-182 in Cancers: A Meta-Analysis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060960