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Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers
Joint Authors
Carrasco, Gonzalo
Sandoval-Bórquez, Alejandra
Saavedra, Kathleen
Garcia-Bloj, Benjamin
Fry, Jacqueline
Wichmann, Ignacio
Corvalan, Alejandro H.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities.
It is a multifactorial disease, and its development depends on infection by Helicobacter pylori (H.
pylori) and Epstein-Barr virus (EBV), host genetic factors, and environmental factors.
The heterogeneity of the disease has begun to be unraveled by a comprehensive mutational evaluation of primary tumors.
The low-abundance of mutations suggests that other mechanisms participate in the evolution of the disease, such as those found through analyses of noncoding genomics.
Noncoding genomics includes single nucleotide polymorphisms (SNPs), regulation of gene expression through DNA methylation of promoter sites, miRNAs, other noncoding RNAs in regulatory regions, and other topics.
These processes and molecules ultimately control gene expression.
Potential biomarkers are appearing from analyses of noncoding genomics.
This review focuses on noncoding genomics and potential biomarkers in the context of gastric cancer and the gastric precancerous cascade.
American Psychological Association (APA)
Sandoval-Bórquez, Alejandra& Saavedra, Kathleen& Carrasco, Gonzalo& Garcia-Bloj, Benjamin& Fry, Jacqueline& Wichmann, Ignacio…[et al.]. 2015. Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers. Disease Markers،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1060962
Modern Language Association (MLA)
Sandoval-Bórquez, Alejandra…[et al.]. Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers. Disease Markers No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1060962
American Medical Association (AMA)
Sandoval-Bórquez, Alejandra& Saavedra, Kathleen& Carrasco, Gonzalo& Garcia-Bloj, Benjamin& Fry, Jacqueline& Wichmann, Ignacio…[et al.]. Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1060962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060962