Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis
Joint Authors
Fan, Zhe
Pan, Jiyong
Zhang, Yingyi
Wang, Ziyi
Zhu, Ming
Yang, Baoshun
Shi, Lei
Jing, Huirong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Introduction.
Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively.
We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA.
Aims.
To evaluate whether or not the MPV and PDW are suitable markers to diagnose AGA.
Methods.
A retrospective study of 160 patients with AGA and 160 healthy patients was undertaken.
Disease diagnosis was confirmed based on the pathologic examination of surgical specimens.
Patient white blood cell (WBC) count, neutrophil ratio (NR), platelet (PLT) count, MPV, PDW, and hematocrit (HCT) were analyzed.
Receiver operating characteristic (ROC) curves were used to evaluate the sensitivity and specificity of these indices in AGA.
Results.
There were no significant differences between the AGA and control groups in age and gender.
Compared to the control group, the WBC count, NR, and PDW were significantly higher ( P < 0.001 , resp.) and the MPV and HCT were significantly lower ( P < 0.001 , resp.) in the AGA group.
The diagnostic specificities of the WBC count, NR, PLT count, MPV, PDW, and HCT were 86.3%, 92.5%, 58.1%, 81.7%, 83.9%, and 66.3%, respectively.
Therefore, the NR had the highest diagnostic specificity for the diagnosis of AGA.
Conclusions.
This is the first study to assess the MPV and PDW in patients with AGA.
Our present study showed that the MPV is reduced and the PDW is increased in patients with AGA; the sensitivity of PDW was superior to the MPV.
A decreased MPV value and an increased PDW could serve as two markers to diagnose AGA.
The NR had the highest specificity for the diagnosis of AGA.
American Psychological Association (APA)
Fan, Zhe& Pan, Jiyong& Zhang, Yingyi& Wang, Ziyi& Zhu, Ming& Yang, Baoshun…[et al.]. 2015. Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis. Disease Markers،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1060972
Modern Language Association (MLA)
Fan, Zhe…[et al.]. Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis. Disease Markers No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1060972
American Medical Association (AMA)
Fan, Zhe& Pan, Jiyong& Zhang, Yingyi& Wang, Ziyi& Zhu, Ming& Yang, Baoshun…[et al.]. Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1060972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060972