The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs
Joint Authors
Tahir, Asma I.
Nguyen, Cao
Lykowska-Tarnowska, Agnieszka
Morahan, Grant
Muiya, Nzioka P.
Meyer, Brian F.
Dzimiri, Nduna
Wakil, Salma M.
Andres, Editha
Baz, Batoul
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus Premier Pack has been designed to genotype 1936 gene variants thought to be essential for screening patients in personalized drug therapy.
These variants include the cytochrome P450s (CYP450s), the key metabolizing enzymes, many other enzymes involved in phase I and phase II pharmacokinetic reactions, and signaling mediators associated with variability in clinical response to numerous drugs not only among individuals, but also between ethnic populations.
Materials and Methods.
We genotyped 600 Saudi individuals for 1936 variants on the DMET platform to evaluate their clinical potential in personalized medicine in ethnic Arabs.
Results.
Approximately 49% each of the 437 CYP450 variants, 56% of the 581 transporters, 56% of 419 transferases, 48% of the 104 dehydrogenases, and 58% of the remaining 390 variants were detected.
Several variants, such as rs3740071, rs6193, rs258751, rs6199, rs11568421, and rs8187797, exhibited significantly either higher or lower minor allele frequencies (MAFs) than those in other ethnic groups.
Discussion.
The present study revealed some unique distribution trends for several variants in Arabs, which displayed partly inverse allelic prevalence compared to other ethnic populations.
The results point therefore to the need to verify and ascertain the prevalence of a variant as a prerequisite for engaging it in clinical routine screening in personalized medicine in any given population.
American Psychological Association (APA)
Wakil, Salma M.& Nguyen, Cao& Muiya, Nzioka P.& Andres, Editha& Lykowska-Tarnowska, Agnieszka& Baz, Batoul…[et al.]. 2015. The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060973
Modern Language Association (MLA)
Wakil, Salma M.…[et al.]. The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1060973
American Medical Association (AMA)
Wakil, Salma M.& Nguyen, Cao& Muiya, Nzioka P.& Andres, Editha& Lykowska-Tarnowska, Agnieszka& Baz, Batoul…[et al.]. The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1060973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060973