Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis
Joint Authors
Song, Yong-xi
Huang, Xuan-zhang
Gao, Peng
Sun, Jing-xu
Chen, Xiao-wan
Yang, Yu-chong
Zhang, Cong
Liu, Hong-peng
Wang, Hong-chi
Wang, Zhen-ning
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The clinical value of carbohydrate antigen (CA) 19-9 in gastric cancer is controversial.
We evaluated the clinicopathologic and prognostic value of CA 19-9 in gastric cancer.
Methods.
A literature search was conducted in PubMed and Embase databases.
Odds ratios (ORs), risk ratios (RR), hazard ratios (HRs), and 95% confidence intervals (CIs) were used as effect measures.
Results.
Thirty-eight studies were included.
Results showed that there were significant differences in the incidence of high CA 19-9 levels between stages III/IV and I/II groups (OR = 3.36; 95% CI = 2.34–4.84), the pT3/T4 and pT1/T2 groups (OR = 2.40; 95% CI = 1.60–3.59), the lymph node-positive and node-negative groups (OR = 2.91; 95% CI = 2.21–3.84), the metastasis-positive and metastasis-negative groups (OR = 2.76; 95% CI = 1.12–6.82), and vessel invasion-positive and invasion-negative groups (OR = 1.66; 95% CI = 1.11–2.48).
Moreover, CA 19-9 was significantly associated with poor overall survival (HR = 1.83; 95% CI = 1.56–2.15), disease-free survival (HR = 1.85; 95% CI = 1.16–2.95), and disease-specific survival (HR = 1.33; 95% CI = 1.10–1.60) in gastric cancer.
Conclusions.
Our meta-analysis showed that CA 19-9 indicates clinicopathologic characteristics of gastric cancer and is associated with a poor prognosis.
American Psychological Association (APA)
Song, Yong-xi& Huang, Xuan-zhang& Gao, Peng& Sun, Jing-xu& Chen, Xiao-wan& Yang, Yu-chong…[et al.]. 2015. Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis. Disease Markers،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060978
Modern Language Association (MLA)
Song, Yong-xi…[et al.]. Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis. Disease Markers No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1060978
American Medical Association (AMA)
Song, Yong-xi& Huang, Xuan-zhang& Gao, Peng& Sun, Jing-xu& Chen, Xiao-wan& Yang, Yu-chong…[et al.]. Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1060978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060978