Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy
Joint Authors
Shen, Jie
Li, Zhangfang
Li, Wenting
Ge, Ying
Xie, Min
Lv, Meng
Fan, Yanfei
Chen, Zhi
Zhao, Defu
Han, Yajuan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To determine serum cytokine profiles in Graves’ disease (GD) patients with or without active and inactive thyroid associated ophthalmopathy (TAO), we recruited 65 subjects: 10 GD only (without TAO), 25 GD + active TAO, 20 GD + TAO, and 10 healthy controls.
Liquid chip assay was used to measure serum Th1/Th2/Th17 cytokines including IFN-γ (interferon-gamma), TNF-α (tumor necrosis factor-alpha), IL-1α (interleukin-1 alpha), IL-1Ra (IL-1 receptor antagonist), IL-2, IL-4, IL-6, and IL-17 and two chemokines: RANTES (regulated upon activation, normal T cell expressed and secreted) and IP-10 (IFN-γ-induced protein 10).
Serum levels of TSH (thyroid stimulating hormone) receptor autoantibodies (TRAb) were measured using an enzyme linked immunosorbent assay.
Compared with healthy controls, TAO patients showed significantly elevated serum levels of IFN-γ, TNF-α, IL-1α, IL-4, IL-6, IL-17, and IP-10.
Comparing active and inactive TAO, serum Th1 cytokines IFN-γ and TNF-α were elevated in active TAO, while serum Th2 cytokine IL-4 was elevated in inactive TAO.
Serum Th17 cytokine IL-17 was elevated in GD but reduced in both active and inactive TAO.
A positive correlation was found between TRAb and IFN-γ, TNF-α, IL-1α, IL-2, IL-4, and IL-6.
Taken together, serum Th1/Th2/Th17 cytokines and chemokines reflect TAO disease activity and may be implicated in TAO pathogenesis.
American Psychological Association (APA)
Shen, Jie& Li, Zhangfang& Li, Wenting& Ge, Ying& Xie, Min& Lv, Meng…[et al.]. 2015. Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060990
Modern Language Association (MLA)
Shen, Jie…[et al.]. Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060990
American Medical Association (AMA)
Shen, Jie& Li, Zhangfang& Li, Wenting& Ge, Ying& Xie, Min& Lv, Meng…[et al.]. Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060990