Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma
Joint Authors
Dong, Chao
Wang, Xiao-li
Ma, Bin-lin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis.
At present, there are fewer researches on the relationship between SKA1 expression and tumor development.
Methods.
In this study, immunohistochemical analysis was used to determine the expression of SKA1 in papillary thyroid carcinoma (PTC) and adjacent tissues.
We used quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis to further verify the results.
Results.
We found that SKA1 expression was significantly higher in PTC tissues than normal adjacent tissues ( P < 0.05 ) .
There existed a significant correlation among a higher SKA1 expression, including lymphoid node ( P = 0.005 ) , clinical stage ( P = 0.015 ) , and extrathyroid invasion ( P = 0.004 ) .
Survival analysis showed high SKA1 expression in PTC patients more likely to relapse after surgery.
Conclusion.
High SKA1 expression is predictive of poor prognosis of PTC, implying that SKA1 may be a promising new target for targeted therapies for PTC.
American Psychological Association (APA)
Dong, Chao& Wang, Xiao-li& Ma, Bin-lin. 2015. Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060993
Modern Language Association (MLA)
Dong, Chao…[et al.]. Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1060993
American Medical Association (AMA)
Dong, Chao& Wang, Xiao-li& Ma, Bin-lin. Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1060993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060993