Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk
Joint Authors
Bănescu, Claudia
Dobreanu, Minodora
Moţăţăianu, Anca
Bălaşa, Rodica
Voidăzan, Septimiu
Moldovan, Valeriu G.
Stoian, Adina
Stoian, Mircea
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aims.
Diabetic neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM).
Genetic susceptibility and oxidative stress may play a role in the appearance of T2DM and diabetic neuropathy.
We investigated the relation between polymorphism in genes related to oxidative stress such as GSTM1, GSTT1, and GSTP1 and the presence of T2DM and diabetic neuropathy (DN).
Methods.
Samples were collected from 84 patients with T2DM (42 patients with DN and 42 patients without DN) and 98 healthy controls and genotyped by using polymerase chain reaction and restriction fragment length polymorphism method.
Results.
GSTP1 Ile105Val polymorphism was associated with the risk of developing T2DM (p=0.05) but not with the risk of developing DN in diabetic cases.
GSTM1 and GSTT1 gene polymorphisms were associated with neither the risk of developing T2DM nor the risk of DN occurrence in diabetic patients.
No association was observed between the patients with T2DM and DSPN (diabetic sensorimotor peripheral neuropathy) and T2DM without DSPN regarding investigated polymorphism.
Conclusion.
Our data suggest that GSTP1 gene polymorphisms may contribute to the development of T2DM in Romanian population.
GSTM1, GSTT1, and GSTP1 gene polymorphisms are not associated with susceptibility of developing diabetic neuropathy in T2DM patients.
American Psychological Association (APA)
Stoian, Adina& Bănescu, Claudia& Bălaşa, Rodica& Moţăţăianu, Anca& Stoian, Mircea& Moldovan, Valeriu G.…[et al.]. 2015. Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk. Disease Markers،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060998
Modern Language Association (MLA)
Stoian, Adina…[et al.]. Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk. Disease Markers No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1060998
American Medical Association (AMA)
Stoian, Adina& Bănescu, Claudia& Bălaşa, Rodica& Moţăţăianu, Anca& Stoian, Mircea& Moldovan, Valeriu G.…[et al.]. Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1060998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1060998