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Procalcitonin Levels in Gram-Positive, Gram-Negative, and Fungal Bloodstream Infections
Joint Authors
Ferranti, Marta
Moretti, Amedeo
Al Dhahab, Zainab Salim
Cenci, Elio
Mencacci, Antonella
Leli, Christian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Procalcitonin (PCT) can discriminate bacterial from viral systemic infections and true bacteremia from contaminated blood cultures.
The aim of this study was to evaluate PCT diagnostic accuracy in discriminating Gram-positive, Gram-negative, and fungal bloodstream infections.
A total of 1,949 samples from patients with suspected bloodstream infections were included in the study.
Median PCT value in Gram-negative (13.8 ng/mL, interquartile range (IQR) 3.4–44.1) bacteremias was significantly higher than in Gram-positive (2.1 ng/mL, IQR 0.6–7.6) or fungal (0.5 ng/mL, IQR 0.4–1) infections ( P < 0.0001 ).
Receiver operating characteristic analysis showed an area under the curve (AUC) for PCT of 0.765 (95% CI 0.725–0.805, P < 0.0001 ) in discriminating Gram-negatives from Gram-positives at the best cut-off value of 10.8 ng/mL and an AUC of 0.944 (95% CI 0.919–0.969, P < 0.0001 ) in discriminating Gram-negatives from fungi at the best cut-off of 1.6 ng/mL.
Additional results showed a significant difference in median PCT values between Enterobacteriaceae and nonfermentative Gram-negative bacteria (17.1 ng/mL, IQR 5.9–48.5 versus 3.5 ng/mL, IQR 0.8–21.5; P < 0.0001 ).
This study suggests that PCT may be of value to distinguish Gram-negative from Gram-positive and fungal bloodstream infections.
Nevertheless, its utility to predict different microorganisms needs to be assessed in further studies.
American Psychological Association (APA)
Leli, Christian& Ferranti, Marta& Moretti, Amedeo& Al Dhahab, Zainab Salim& Cenci, Elio& Mencacci, Antonella. 2015. Procalcitonin Levels in Gram-Positive, Gram-Negative, and Fungal Bloodstream Infections. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061016
Modern Language Association (MLA)
Leli, Christian…[et al.]. Procalcitonin Levels in Gram-Positive, Gram-Negative, and Fungal Bloodstream Infections. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061016
American Medical Association (AMA)
Leli, Christian& Ferranti, Marta& Moretti, Amedeo& Al Dhahab, Zainab Salim& Cenci, Elio& Mencacci, Antonella. Procalcitonin Levels in Gram-Positive, Gram-Negative, and Fungal Bloodstream Infections. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061016