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Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome
Joint Authors
Sousa, António
Raposo, Frederico
Fonseca, Sara
Valente, Luís
Duarte, Filipe
Gonçalves, Moura
Tuna, Diana
Paiva, José-Artur
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Severity and outcome assessments are crucial in trauma.
Our aim was to describe the role of a group of cytokines (TNFα, IL-6, IL-10, and HMGB-1) and ICAM-1 as severity and outcome assessment tools and their kinetics in the first 72 h after severe trauma.
Materials and Methods.
Authors designed a prospective cohort study of severe polytrauma patients (ISS > 15) in a level 1 Trauma Centre.
Cytokines and ICAM-1 levels and Th1/Th2 ratios were assessed at admission, 24, 48, and 72 h.
SIRS, SIRS with hypoperfusion, and shock were identified.
Outcomes considered were ICU admission, ARDS, MODS, and death.
Results.
Ninety-nine patients were enrolled (median ISS: 29 and age 31).
There was an early release of pro- and anti-inflammatory mediators with higher values at admission (except for ICAM-1).
On admission, IL-6 was associated with ISS, IL-10 with SIRS with hypoperfusion, and HMGB-1 with shock.
Several cytokines were associated with outcomes, especially IL-6 and IL-10 at 72 h with MODS and death.
Low TNFα/IL-10 and IL-6/IL-10 ratios at 24 and 72 h were associated with MODS and death.
Conclusions.
Pro- and anti-inflammatory responses occur simultaneously and earlier after injury.
Cytokines may be useful for outcome assessment, especially IL-6 and IL-10.
Low Th1/Th2 ratio at 24 to 72 h is associated with MODS and death.
American Psychological Association (APA)
Sousa, António& Raposo, Frederico& Fonseca, Sara& Valente, Luís& Duarte, Filipe& Gonçalves, Moura…[et al.]. 2015. Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061029
Modern Language Association (MLA)
Sousa, António…[et al.]. Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061029
American Medical Association (AMA)
Sousa, António& Raposo, Frederico& Fonseca, Sara& Valente, Luís& Duarte, Filipe& Gonçalves, Moura…[et al.]. Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061029