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Sequence Variants of Peroxisome Proliferator-Activated Receptor-Gamma Gene and the Clinical Courses of Patients with End-Stage Renal Disease
Joint Authors
Chiang, Chih-Kang
Chao, Chia-Ter
Chen, Yen-Ching
Huang, Jenq-Wen
Hu, Fu-Chang
Fang, Cheng-Chung
Chang, Chen-Chih
Yen, Chung-Jen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
PPAR-γ single nucleotide polymorphisms (SNPs) reportedly play an important role in determining metabolic risk among diverse population.
Whether PPAR-γ SNPs affect the clinical courses in ESRD patients is unknown.
Methods.
From a multicenter cohort, we identified 698 patients with prevalent ESRD between 2002 and 2003, and other 782 healthy subjects as control.
Two PPAR-γ SNPs, Pro12Ala (rs1801282) and C161T (rs3856806), were genotyped and their association with ESRD was examined.
Both groups were prospectively followed until 2007, and the predictability of genotypes for the long-term survival of ESRD patients was analyzed.
Results.
After multivariable-adjusted regression, GG genotype of Pro12Ala was significantly more likely to associate with ESRD ( P < 0.001 ) among patients with non-diabetes-related ESRD.
Cox’s proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001 ; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001 ; CT versus TT genotypes, HR 1.93; P < 0.001 ).
Conclusion.
This is the first and largest study to evaluate PPAR-γ SNPs in ESRD patients.
Further mechanistic study is needed to elucidate the role of PPAR-γ among ESRD patients.
American Psychological Association (APA)
Chao, Chia-Ter& Chen, Yen-Ching& Chiang, Chih-Kang& Huang, Jenq-Wen& Hu, Fu-Chang& Fang, Cheng-Chung…[et al.]. 2015. Sequence Variants of Peroxisome Proliferator-Activated Receptor-Gamma Gene and the Clinical Courses of Patients with End-Stage Renal Disease. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061037
Modern Language Association (MLA)
Chao, Chia-Ter…[et al.]. Sequence Variants of Peroxisome Proliferator-Activated Receptor-Gamma Gene and the Clinical Courses of Patients with End-Stage Renal Disease. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061037
American Medical Association (AMA)
Chao, Chia-Ter& Chen, Yen-Ching& Chiang, Chih-Kang& Huang, Jenq-Wen& Hu, Fu-Chang& Fang, Cheng-Chung…[et al.]. Sequence Variants of Peroxisome Proliferator-Activated Receptor-Gamma Gene and the Clinical Courses of Patients with End-Stage Renal Disease. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061037