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VEGF Overexpression Is a Valuable Prognostic Factor for Non-Hodgkin’s Lymphoma Evidence from a Systemic Meta-Analysis
Joint Authors
Yang, Jing
Li, Wenlu
He, Xin
Zhang, Guofei
Yue, Lan
Chai, Ying
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Vascular endothelial growth factor (VEGF) plays a vital role in the progression of Non-Hodgkin’s lymphoma (NHL).
Although multiple studies have investigated the relationship between VEGF expression and prognosis of NHL, these studies have yielded conflicting results.
Therefore, we performed a meta-analysis to evaluate the role of VEGF in the prognosis of NHL patients.
We systematically searched eligible studies from databases and determined that there was a significant correlation between VEGF overexpression and overall survival (HR (hazard ratio) = 1.66, 95% CI: 1.25–2.22, P=0.001).
Based on subgroup analysis by study location, number of patients, the source of VEGF expression, and study design, we found that VEGF overexpression in surgically resected tissue (HR = 1.95, 95% CI: 1.41–2.69, P=0.000), but not in serum (HR = 1.37, 95% CI: 0.96–1.95, P=0.087), was associated with poorer prognosis.
Additionally, VEGF overexpression did not correlate with performance status, LDH level, IPI score, tumor staging, B symptoms, or NHL relapse.
In summary, overexpression of VEGF in lymphoma tissue represents a promising potential prognostic factor in NHL.
American Psychological Association (APA)
Yang, Jing& Li, Wenlu& He, Xin& Zhang, Guofei& Yue, Lan& Chai, Ying. 2015. VEGF Overexpression Is a Valuable Prognostic Factor for Non-Hodgkin’s Lymphoma Evidence from a Systemic Meta-Analysis. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061041
Modern Language Association (MLA)
Yang, Jing…[et al.]. VEGF Overexpression Is a Valuable Prognostic Factor for Non-Hodgkin’s Lymphoma Evidence from a Systemic Meta-Analysis. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061041
American Medical Association (AMA)
Yang, Jing& Li, Wenlu& He, Xin& Zhang, Guofei& Yue, Lan& Chai, Ying. VEGF Overexpression Is a Valuable Prognostic Factor for Non-Hodgkin’s Lymphoma Evidence from a Systemic Meta-Analysis. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061041