Plasma Interleukin-37 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1Th2Th17-Related Cytokines
Joint Authors
Wei, Xiao-Qing
Xia, Ting
Zheng, Xing-feng
Qian, Bao-hua
Fang, He
Wang, Jun-jie
Zhang, Lan-ling
Pang, Ya-fei
Zhang, Ju
Xia, Zhao-fan
Zhao, Dong-bao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Interleukin- (IL-) 37 is a novel anti-inflammatory cytokine that suppresses immune response and inflammation.
This study was performed to determine whether IL-37 was elevated in patients with rheumatoid arthritis (RA) and investigate the correlation between IL-37 level and disease activity and the concentration of Th1/Th2/Th17-related cytokines.
Clinical parameters of disease activity, including the 28-joint disease activity score (DAS28) and C-reactive protein (CRP), were collected in 34 RA patients and 34 age- and sex-matched healthy controls.
Plasma IL-37 was measured by ELISA.
Plasma levels of TNF-α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, G-CSF, GM-CSF, IFN-γ, MCP-1, and MIP-1β were analyzed using the Bio-Plex suspension array system.
It was found that IL-37 levels were elevated markedly in RA patients and almost undetectable in healthy controls.
In addition, IL-37 levels in patients with active RA were significantly enhanced as compared with those in patients of remission.
More importantly, IL-37 showed a significant correlation with disease activity (DAS28) and IL-4, IL-7, IL-10, IL-12, and IL-13 concentrations in RA patients.
These findings suggest that IL-37 plays an important role in the pathogenesis of RA and may prove to be a potential biomarker of active RA.
American Psychological Association (APA)
Xia, Ting& Zheng, Xing-feng& Qian, Bao-hua& Fang, He& Wang, Jun-jie& Zhang, Lan-ling…[et al.]. 2015. Plasma Interleukin-37 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1Th2Th17-Related Cytokines. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061043
Modern Language Association (MLA)
Xia, Ting…[et al.]. Plasma Interleukin-37 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1Th2Th17-Related Cytokines. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061043
American Medical Association (AMA)
Xia, Ting& Zheng, Xing-feng& Qian, Bao-hua& Fang, He& Wang, Jun-jie& Zhang, Lan-ling…[et al.]. Plasma Interleukin-37 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1Th2Th17-Related Cytokines. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061043