Procalcitonin Improves the Glasgow Prognostic Score for Outcome Prediction in Emergency Patients with Cancer: A Cohort Study
Joint Authors
Rast, Anna Christina
Kutz, Alexander
Felder, Susan
Faessler, Lukas
Steiner, Deborah
Laukemann, Svenja
Haubitz, Sebastian
Huber, Andreas
Buergi, Ulrich
Conca, Antoinette
Reutlinger, Barbara
Mueller, Beat
Bargetzi, Mario
Schuetz, Philipp
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The Glasgow Prognostic Score (GPS) is useful for predicting long-term mortality in cancer patients.
Our aim was to validate the GPS in ED patients with different cancer-related urgency and investigate whether biomarkers would improve its accuracy.
We followed consecutive medical patients presenting with a cancer-related medical urgency to a tertiary care hospital in Switzerland.
Upon admission, we measured procalcitonin (PCT), white blood cell count, urea, 25-hydroxyvitamin D, corrected calcium, C-reactive protein, and albumin and calculated the GPS.
Of 341 included patients (median age 68 years, 61% males), 81 (23.8%) died within 30 days after admission.
The GPS showed moderate prognostic accuracy (AUC 0.67) for mortality.
Among the different biomarkers, PCT provided the highest prognostic accuracy (odds ratio 1.6 (95% confidence interval 1.3 to 1.9), P < 0.001 , AUC 0.69) and significantly improved the GPS to a combined AUC of 0.74 ( P = 0.007 ).
Considering all investigated biomarkers, the AUC increased to 0.76 ( P < 0.001 ).
The GPS performance was significantly improved by the addition of PCT and other biomarkers for risk stratification in ED cancer patients.
The benefit of early risk stratification by the GPS in combination with biomarkers from different pathways should be investigated in further interventional trials.
American Psychological Association (APA)
Rast, Anna Christina& Kutz, Alexander& Felder, Susan& Faessler, Lukas& Steiner, Deborah& Laukemann, Svenja…[et al.]. 2015. Procalcitonin Improves the Glasgow Prognostic Score for Outcome Prediction in Emergency Patients with Cancer: A Cohort Study. Disease Markers،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061044
Modern Language Association (MLA)
Rast, Anna Christina…[et al.]. Procalcitonin Improves the Glasgow Prognostic Score for Outcome Prediction in Emergency Patients with Cancer: A Cohort Study. Disease Markers No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061044
American Medical Association (AMA)
Rast, Anna Christina& Kutz, Alexander& Felder, Susan& Faessler, Lukas& Steiner, Deborah& Laukemann, Svenja…[et al.]. Procalcitonin Improves the Glasgow Prognostic Score for Outcome Prediction in Emergency Patients with Cancer: A Cohort Study. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061044