Polymorphisms in C-Reactive Protein and Glypican-5 Are Associated with Lung Cancer Risk and Gartrokine-1 Influences Cisplatin-Based Chemotherapy Response in a Chinese Han Population
Joint Authors
Zhang, Shuo
Thakur, Asmitananda
Liang, Yiqian
Wang, Ting
Gao, Lei
Yang, Tian
Li, Yang
Geng, Tingting
Jin, Tianbo
Chen, Tianjun
Liu, Johnson J.
Chen, Mingwei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The role of genetics in progression of cancer is an established fact, and susceptibility risk and difference in outcome to chemotherapy may be caused by the variation in low-penetrance alleles of risk genes.
We selected seven genes (CRP, GPC5, ACTA2, AGPHD1, SEC14L5, RBMS3, and GKN1) that previously reported link to lung cancer (LC) and genotyped single nucleotide polymorphisms (SNPs) of these genes in a case-control study.
A protective allele “C” was found in rs2808630 of the C-reactive protein (CRP).
Model association analysis found genotypes “T/C” and “C/C” in the dominant model and genotype “T/C” in the overdominant model of rs2808630 associated with reduced LC risk.
Gender-specific analysis in each model showed that genotypes “T/T” and “C/C” in rs2352028 of the Glypican 5 (GPC5) were associated with increased LC risk in males.
Logistic regression analysis showed “C/T” genotype carriers of rs4254535 in the Gastrokine 1 (GKN1) had less likelihood to have chemotherapy response.
Our results suggest a potential association between CRP and GPC5 variants with LC risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population.
American Psychological Association (APA)
Zhang, Shuo& Thakur, Asmitananda& Liang, Yiqian& Wang, Ting& Gao, Lei& Yang, Tian…[et al.]. 2015. Polymorphisms in C-Reactive Protein and Glypican-5 Are Associated with Lung Cancer Risk and Gartrokine-1 Influences Cisplatin-Based Chemotherapy Response in a Chinese Han Population. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061051
Modern Language Association (MLA)
Zhang, Shuo…[et al.]. Polymorphisms in C-Reactive Protein and Glypican-5 Are Associated with Lung Cancer Risk and Gartrokine-1 Influences Cisplatin-Based Chemotherapy Response in a Chinese Han Population. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061051
American Medical Association (AMA)
Zhang, Shuo& Thakur, Asmitananda& Liang, Yiqian& Wang, Ting& Gao, Lei& Yang, Tian…[et al.]. Polymorphisms in C-Reactive Protein and Glypican-5 Are Associated with Lung Cancer Risk and Gartrokine-1 Influences Cisplatin-Based Chemotherapy Response in a Chinese Han Population. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061051