Coenzyme Q10, α-Tocopherol, and Oxidative Stress Could Be Important Metabolic Biomarkers of Male Infertility
Joint Authors
Singh, R. B.
Kucharska, Jarmila
Gvozdjakova, Anna
Dubravicky, Jozef
Mojto, Viliam
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oxidative stress, decreased antioxidant capacity, and impaired sperm mitochondrial function are the main factors contributing to male infertility.
The goal of the present study was to assess the effect of the per os treatment with Carni-Q-Nol (440 mg L-carnitine fumarate + 30 mg ubiquinol + 75 IU vitamin E + 12 mg vitamin C in each softsule) in infertile men on sperm parameters, concentration of antioxidants (coenzyme Q10, CoQ10-TOTAL, γ, and α-tocopherols), and oxidative stress in blood plasma and seminal fluid.
Forty infertile men were supplemented daily with two or three Carni-Q-Nol softsules.
After 3 and 6 months of treatment, improved sperm density was observed (by 48.9% and 80.9%, resp.) and after 3-month treatment the sperm pathology decreased by 25.8%.
Concentrations of CoQ10-TOTAL (ubiquinone + ubiquinol) and α-tocopherol were significantly increased and the oxidative stress was decreased.
In conclusion, the effect of supplementary therapy with Carni-Q-Nol showed benefits on sperm function in men, resulting in 45% pregnancies of their women.
We assume that assessment of oxidative stress, CoQ10-TOTAL, and α-tocopherol in blood plasma and seminal fluid could be important metabolic biomarkers in both diagnosis and treatment of male infertility.
American Psychological Association (APA)
Gvozdjakova, Anna& Kucharska, Jarmila& Dubravicky, Jozef& Mojto, Viliam& Singh, R. B.. 2015. Coenzyme Q10, α-Tocopherol, and Oxidative Stress Could Be Important Metabolic Biomarkers of Male Infertility. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061055
Modern Language Association (MLA)
Gvozdjakova, Anna…[et al.]. Coenzyme Q10, α-Tocopherol, and Oxidative Stress Could Be Important Metabolic Biomarkers of Male Infertility. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061055
American Medical Association (AMA)
Gvozdjakova, Anna& Kucharska, Jarmila& Dubravicky, Jozef& Mojto, Viliam& Singh, R. B.. Coenzyme Q10, α-Tocopherol, and Oxidative Stress Could Be Important Metabolic Biomarkers of Male Infertility. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061055