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MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain
Joint Authors
Campillo, José Antonio
López-Hernández, Ruth
Martínez-Banaclocha, Helios
Bolarín, José Miguel
Gimeno, Lourdes
Mrowiec, Anna
López, Manuela
Heras, Beatriz Las
Minguela, Alfredo
Moya-Quiles, Maria Rosa
Legáz, Isabel
Frías-Iniesta, José Francisco
García-Alonso, Ana María
Álvarez-López, María Rocío
Martínez-Escribano, Jorge Antonio
Muro, Manuel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A limited number of studies have been performed so far on the polymorphism in the transmembrane region (exon 5) of the major histocompatibility complex class I chain-related gene A (MICA) in patients with melanoma.
However, the influence of MICA polymorphism in extracellular domains (exons 2, 3, and 4) has not been investigated on melanoma disease.
This study aims to characterize the influence of extracellular MICA polymorphism, and its previously described linkage disequilibrium with HLA-B locus, on patients with cutaneous melanoma from southeastern Spain.
For this purpose, MICA and HLA-B genotyping was performed in 233 patients and 200 ethnically matched controls by luminex technology.
Patients were classified according to the presence of methionine or valine at codon 129 of MICA gene.
We found a high frequency of MICA*009 in melanoma patients compared with controls (P=0.002, Pc = 0.03).
Our results also showed an association between MICA*009 and HLA-B*51 alleles in both patients and controls.
This association was stronger in patients than controls (P=0.015).
However, a multivariate logistic regression model showed that neither MICA*009 nor the combination MICA*009/HLA-B*51 was associated with melanoma susceptibility.
No relationship was observed between MICA-129 dimorphism and melanoma nor when MICA polymorphism was evaluated according to clinical findings at diagnosis.
American Psychological Association (APA)
Campillo, José Antonio& López-Hernández, Ruth& Martínez-Banaclocha, Helios& Bolarín, José Miguel& Gimeno, Lourdes& Mrowiec, Anna…[et al.]. 2015. MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061058
Modern Language Association (MLA)
Campillo, José Antonio…[et al.]. MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061058
American Medical Association (AMA)
Campillo, José Antonio& López-Hernández, Ruth& Martínez-Banaclocha, Helios& Bolarín, José Miguel& Gimeno, Lourdes& Mrowiec, Anna…[et al.]. MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061058