Association between Programmed Cell Death 6 Interacting Protein InsertionDeletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population

Abstract EN

It has been suggested that genetic factors contribute to patients’ vulnerability to breast cancer (BC).

The programmed cell death 6 interacting protein (PDCD6IP) encodes for a protein that is known to bind to the products of the PDCD6 gene, which is involved in the apoptosis pathway.

The aim of this case-control study is to investigate the relationship between the PDCD6IP 15 bp insertion/deletion (I/D) polymorphism (rs28381975) and BC risk in an Iranian population.

A total of 491 females, including 266 BC patients and 225 control subjects without cancer, were enrolled into the study.

Our findings revealed that the PDCD6IP 15 bp I/D polymorphism decreased the risk of BC in codominant ( OR = 0.44 , 95% CI = 0.31 –0.65, p < 0.0001 , I/D versus DD; OR = 0.39 , 95% CI = 0.17 –0.88, p = 0.030 , I/I versus DD) and dominant ( OR = 0.44 , 95% CI = 0.30 –0.63, p < 0.0001 , D/I + I/I versus D/D) tested inheritance models.

Also, the PDCD6IP I allele significantly decreased the risk of BC ( OR = 0.59 , 95% CI = 0.45 –0.78, p < 0.001 ) compared to the D allele.