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NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population
Joint Authors
Villasmil, Ángel
Takiff, Howard
Fuentes Alcalá, Zhenia
Fernández-Mestre, Mercedes
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Natural resistance-associated macrophage protein (Nramp1) and the vitamin D receptor (VDR) are central components of the innate and adaptive immunity against Mycobacterium tuberculosis, and associations between susceptibility to tuberculosis and polymorphisms in the genes NRAMP and VDR have been sought in geographically diverse populations.
We investigated associations of NRAMP1 and VDR gene polymorphisms with susceptibility to TB in the Venezuelan population.
The results suggest the absence of any association between VDR variants FokI, ApaI, and TaqI and susceptibility to tuberculosis.
In contrast, the NRAMP1 3′UTR variants were associated with susceptibility to M.
tuberculosis infection, as seen in the comparisons between TST+ and TST− controls, and also with progression to TB disease, as shown in the comparisons between TB patients and TST+ controls.
This study confirms the previously described association of the NRAMP1 3′UTR polymorphism with M.
tuberculosis infection and disease progression.
American Psychological Association (APA)
Fernández-Mestre, Mercedes& Villasmil, Ángel& Takiff, Howard& Fuentes Alcalá, Zhenia. 2015. NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061065
Modern Language Association (MLA)
Fernández-Mestre, Mercedes…[et al.]. NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061065
American Medical Association (AMA)
Fernández-Mestre, Mercedes& Villasmil, Ángel& Takiff, Howard& Fuentes Alcalá, Zhenia. NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061065