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The Analysis of Sialylation, N-Glycan Branching, and Expression of O-Glycans in Seminal Plasma of Infertile Men
Joint Authors
Kratz, Ewa M.
Kałuża, Anna
Ferens-Sieczkowska, Mirosława
Zimmer, Mariusz
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Carbohydrates are known to mediate some events involved in successful fertilization.
Although some studies on the glycosylation of seminal plasma proteins are available, the total glycan profile was rarely analyzed as a feature influencing fertilization potential.
In this work we aimed to compare some glycosylation traits in seminal plasma glycoproteins of fertile and infertile men.
The following findings emerge from our studies: (1) in human seminal plasma the presence and alterations of O-linked glycans were observed; (2) the expression of SNA-reactive sialic acid significantly differs between asthenozoospermia and both normozoospermic (fertile and infertile) groups; (3) the expression of PHA-L-reactive highly branched N-glycans was significantly lower in oligozoospermic patients than in both normozoospermic groups.
Indication of the appropriate lectins that would enable the possibly precise determination of the glycan profile seems to be a good supplement to mass spectrum analysis.
Extension of the lectin panel is useful for the further research.
American Psychological Association (APA)
Kratz, Ewa M.& Kałuża, Anna& Zimmer, Mariusz& Ferens-Sieczkowska, Mirosława. 2015. The Analysis of Sialylation, N-Glycan Branching, and Expression of O-Glycans in Seminal Plasma of Infertile Men. Disease Markers،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061082
Modern Language Association (MLA)
Kratz, Ewa M.…[et al.]. The Analysis of Sialylation, N-Glycan Branching, and Expression of O-Glycans in Seminal Plasma of Infertile Men. Disease Markers No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061082
American Medical Association (AMA)
Kratz, Ewa M.& Kałuża, Anna& Zimmer, Mariusz& Ferens-Sieczkowska, Mirosława. The Analysis of Sialylation, N-Glycan Branching, and Expression of O-Glycans in Seminal Plasma of Infertile Men. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061082