Metabolic Serum Profiles for Patients Receiving Allogeneic StemCell Transplantation: The Pretransplant Profile Differs forPatients with and without Posttransplant Capillary Leak Syndrome
Joint Authors
Reikvam, Håkon
Grønningsæter, Ida-Sofie
Ahmed, Aymen Bushra
Hatfield, Kimberley
Bruserud, Øystein
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant complications.
Capillary leak syndrome is a common early posttransplant complication where endothelial cell dysfunction probably contributes to the pathogenesis.
In the present study we investigated whether the pretreatment serum metabolic profile reflects a risk of posttransplant capillary leak syndrome.
We investigated the pretransplant serum levels of 766 metabolites for 80 consecutive allotransplant recipients.
Patients with later capillary leak syndrome showed increased pretherapy levels of metabolites associated with endothelial dysfunction (homocitrulline, adenosine) altered renal regulation of fluid and/or electrolyte balance (betaine, methoxytyramine, and taurine) and altered vascular function (cytidine, adenosine, and methoxytyramine).
Additional bioinformatical analyses showed that capillary leak syndrome was also associated with altered purine/pyrimidine metabolism (i.e., metabolites involved in vascular regulation and endothelial functions), aminoglycosylation (possibly important for endothelial cell functions), and eicosanoid metabolism (also involved in vascular regulation).
Our observations are consistent with the hypothesis that the pretransplant metabolic status can be a marker for posttransplant abnormal fluid and/or electrolyte balance.
American Psychological Association (APA)
Reikvam, Håkon& Grønningsæter, Ida-Sofie& Ahmed, Aymen Bushra& Hatfield, Kimberley& Bruserud, Øystein. 2015. Metabolic Serum Profiles for Patients Receiving Allogeneic StemCell Transplantation: The Pretransplant Profile Differs forPatients with and without Posttransplant Capillary Leak Syndrome. Disease Markers،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061085
Modern Language Association (MLA)
Reikvam, Håkon…[et al.]. Metabolic Serum Profiles for Patients Receiving Allogeneic StemCell Transplantation: The Pretransplant Profile Differs forPatients with and without Posttransplant Capillary Leak Syndrome. Disease Markers No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061085
American Medical Association (AMA)
Reikvam, Håkon& Grønningsæter, Ida-Sofie& Ahmed, Aymen Bushra& Hatfield, Kimberley& Bruserud, Øystein. Metabolic Serum Profiles for Patients Receiving Allogeneic StemCell Transplantation: The Pretransplant Profile Differs forPatients with and without Posttransplant Capillary Leak Syndrome. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061085