![](/images/graphics-bg.png)
Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes
Joint Authors
Stefanini, Ana Carolina B.
da Cunha, Bianca Rodrigues
Henrique, Tiago
Tajara, Eloiza H.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Human kallikrein-related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions.
Their complex network of stimulatory and inhibitory interactions may induce inflammatory and immune responses and contribute to the neoplastic phenotype through the regulation of several cellular processes, such as proliferation, survival, migration, and invasion.
This family of proteases, which includes one of the most useful cancer biomarkers, kallikrein-related peptidase 3 or PSA, also has a protective effect against cancer promoting apoptosis or counteracting angiogenesis and cell proliferation.
Therefore, they represent attractive therapeutic targets and may have important applications in clinical oncology.
Despite being intensively studied, many gaps in our knowledge on several molecular aspects of KLK functions still exist.
This review aims to summarize recent data on their involvement in different processes related to health and disease, in particular those directly or indirectly linked to the neoplastic process.
American Psychological Association (APA)
Stefanini, Ana Carolina B. & da Cunha, Bianca Rodrigues& Henrique, Tiago& Tajara, Eloiza H.. 2015. Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. Disease Markers،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1061086
Modern Language Association (MLA)
Stefanini, Ana Carolina B.…[et al.]. Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. Disease Markers No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1061086
American Medical Association (AMA)
Stefanini, Ana Carolina B. & da Cunha, Bianca Rodrigues& Henrique, Tiago& Tajara, Eloiza H.. Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1061086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061086