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Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination
Joint Authors
Angeletti, Silvia
Lo Presti, Alessandra
Dicuonzo, Giordano
Fioravanti, Marta
De Cesaris, Marina
Fogolari, Marta
Ciccozzi, Massimo
De Florio, Lucia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Elevated cytokines levels correlate with sepsis severity and mortality but their role in the diagnosis is controversial, whereas Procalcitonin (PCT) has been largely used.
Recently, the mid-regional proadrenomedullin (MR-proADM) has been combined with PCT for diagnosis optimization.
In this study the combined measurement of PCT, MR-proADM, and cytokines in patients with sepsis was evaluated.
Methods.
One hundred and four septic patients and 101 controls were enrolled.
Receiver operating characteristic (ROC) analysis and multiple logistic regression were used to evaluate applicant markers for sepsis diagnosis.
Markers with best Odds Ratio (OR) were combined, and the posttest probability and a composite score were computed.
Results.
Based upon ROC curves analysis, PCT, MR-proADM, IL-6, IL-10, TNF-α, and MCP-1 were considered applicant for sepsis diagnosis.
Among these PCT, MR-proADM , IL-6, and TNF-α showed the best OR.
A better posttest probability was found with the combination of PCT with MR-proADM and PCT with IL-6 or TNF-α compared to the single marker.
A composite score of PCT, MR-proADM, and TNF-α showed the best ROC curve in the early diagnosis of sepsis.
Conclusion.
The combination of PCT with other markers should expedite diagnosis and treatment of sepsis optimizing clinical management.
American Psychological Association (APA)
Angeletti, Silvia& Dicuonzo, Giordano& Fioravanti, Marta& De Cesaris, Marina& Fogolari, Marta& Lo Presti, Alessandra…[et al.]. 2015. Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination. Disease Markers،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061087
Modern Language Association (MLA)
Angeletti, Silvia…[et al.]. Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination. Disease Markers No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1061087
American Medical Association (AMA)
Angeletti, Silvia& Dicuonzo, Giordano& Fioravanti, Marta& De Cesaris, Marina& Fogolari, Marta& Lo Presti, Alessandra…[et al.]. Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061087