Study on the Usefulness of APR Scores from the Viewpoint of Proinflammatory Cytokines
Joint Authors
Nakamura, T.
Hatanaka, D.
Yoshioka, T.
Goto, H.
Yamada, Shingo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Delayed diagnosis and treatment of newborn infection adversely impact outcomes.
Clinical laboratory parameters have aimed to obtain the most correct and prompt diagnosis and treatment of this disease.
This study simultaneously observed changes over time in APR as well as proinflammatory cytokines and anti-proinflammatory cytokines and aims to clarify usefulness of APR scores.
Methods.
We evaluated the usefulness of acute phase reactants (APR) in 46 newborns whose serum up to age 7 days had been stored, with comparison of three types (Group I: infection 15, Group F: fetal inflammatory response syndrome 17, and Group C: control 14) of APR-based scores, those of C-reactive protein (CRP), alpha1-acid glycoprotein (AGP), and haptoglobin (Hp), with proinflammatory cytokine levels.
APR scores for CRP, AGP, and Hp and the levels of the proinflammatory cytokines IL-1β, IL-6, IL-8, IL-10, and TNFα were determined.
Results.
The cytokine levels started to increase from age 0 days and then decreased rapidly.
The three APR scores, CRP, AG, and Hp, were elevated at age 0 days and then gradually decreased in infection (Group I) and fetal inflammatory response syndrome (Group F).
The duration of antibiotic administration according to APR scores was significantly shorter in Group F than in Group I.
Conclusion.
This study demonstrated APR scores to be more useful for deciding whether antibiotics should be discontinued than proinflammatory cytokine levels.
American Psychological Association (APA)
Nakamura, T.& Hatanaka, D.& Yoshioka, T.& Yamada, Shingo& Goto, H.. 2015. Study on the Usefulness of APR Scores from the Viewpoint of Proinflammatory Cytokines. Disease Markers،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061091
Modern Language Association (MLA)
Nakamura, T.…[et al.]. Study on the Usefulness of APR Scores from the Viewpoint of Proinflammatory Cytokines. Disease Markers No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061091
American Medical Association (AMA)
Nakamura, T.& Hatanaka, D.& Yoshioka, T.& Yamada, Shingo& Goto, H.. Study on the Usefulness of APR Scores from the Viewpoint of Proinflammatory Cytokines. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061091