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High CD133 Expression in the Nucleus and Cytoplasm Predicts Poor Prognosis in Non-Small Cell Lung Cancer
Joint Authors
Zhu, Huijun
Huang, Jianfei
Huang, Minjie
Feng, Jian
Ni, Songshi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The aim of this study was to investigate the expression of Prominin-1 (CD133) in cancer cells and its potential value as a prognostic indicator of survival in patients with non-small cell lung cancer (NSCLC).
Methods.
Cancerous tissues and matched normal tissues adjacent to the carcinoma from 239 NSCLC patients were obtained immediately after surgery.
Immunohistochemistry of tissue microarrays was used to characterize the expression of CD133 in NSCLC and adjacent tissues.
The correlation of CD133 expression with clinical characteristics and prognosis was determined by statistical analysis.
Results.
CD133 protein expression levels in both the cytoplasm and nucleus were significantly higher in NSCLC tissues compared with corresponding peritumoral tissue ( P < 0.05 ).
CD133 expression in the nucleus of NSCLC cells was related to tumor diameter ( P = 0.027 ), tumor differentiation ( P < 0.001 ), and TNM stage ( P = 0.007 ).
Kaplan-Meier survival and Cox regression analyses revealed that high CD133 expression in the nucleus was an independent predictor of poor prognosis of NSCLC, as was high cytoplasmic CD133 expression ( P < 0.001 ).
Conclusion.
Our findings provide the first evidence that high expression of CD133 in both the nucleus and cytoplasm is associated with poor prognosis in NSCLC.
American Psychological Association (APA)
Huang, Minjie& Zhu, Huijun& Feng, Jian& Ni, Songshi& Huang, Jianfei. 2015. High CD133 Expression in the Nucleus and Cytoplasm Predicts Poor Prognosis in Non-Small Cell Lung Cancer. Disease Markers،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061092
Modern Language Association (MLA)
Huang, Minjie…[et al.]. High CD133 Expression in the Nucleus and Cytoplasm Predicts Poor Prognosis in Non-Small Cell Lung Cancer. Disease Markers No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061092
American Medical Association (AMA)
Huang, Minjie& Zhu, Huijun& Feng, Jian& Ni, Songshi& Huang, Jianfei. High CD133 Expression in the Nucleus and Cytoplasm Predicts Poor Prognosis in Non-Small Cell Lung Cancer. Disease Markers. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061092