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Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity
Joint Authors
Hegab, Doaa Salah
Attia, Mohamed Attia Saad
Source
Dermatology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Vitiligo is an acquired depigmentary skin disorder resulting from autoimmune destruction of melanocytes.
Regulatory T cells (Tregs), specifically CD4+CD25+ and Forkhead box P3+ (FoxP3+) Tregs, acquired notable attention because of their role in a variety of autoimmune pathologies.
Dysregulation of Tregs may be one of the factors that can break tolerance to melanocyte self-antigens and contribute to vitiligo pathogenesis.
Methods.
In order to sustain the role of Tregs in pathogenesis and disease activity of vitiligo, surface markers for CD4+CD25+ and FoxP3+ peripheral Tregs were evaluated by flow cytometry in 80 Egyptian patients with nonsegmental vitiligo in addition to 60 healthy control subjects and correlated with clinical findings.
Results.
Vitiligo patients had significantly decreased numbers of both peripheral CD4+CD25+ and FoxP3+ T cells compared to control subjects (11.49% ± 8.58% of CD4+ T cells versus 21.20% ± 3.08%, and 1.09% ± 0.96% versus 1.44% ± 0.24%, resp., P<0.05 for both).
Peripheral numbers of CD4+CD25+ and FoxP3+ Tregs correlated negatively with VIDA score.
Conclusion.
Treg depletion with impaired immune downregulatory function might play a key role in the autoimmune conditions beyond nonsegmental vitiligo particularly in active cases.
Effective Treg cell-based immunotherapies might be a future hope for patients with progressive vitiligo.
American Psychological Association (APA)
Hegab, Doaa Salah& Attia, Mohamed Attia Saad. 2015. Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity. Dermatology Research and Practice،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061093
Modern Language Association (MLA)
Hegab, Doaa Salah& Attia, Mohamed Attia Saad. Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity. Dermatology Research and Practice No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061093
American Medical Association (AMA)
Hegab, Doaa Salah& Attia, Mohamed Attia Saad. Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity. Dermatology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061093