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Epidermal Permeability Barrier in the Treatment of Keratosis Pilaris
Joint Authors
Kootiratrakarn, Tanawatt
Kampirapap, Kowit
Chunhasewee, Chakkrapong
Source
Dermatology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
To evaluate and compare the efficacy, safety, hydrating properties, and tolerability of 10% lactic acid (LA) and 5% salicylic acid (SA) in the therapy of keratosis pilaris (KP).
Material and Method.
Patients with KP were randomized for treatment with either 10% LA or 5% SA creams being applied twice daily for 3 months.
The patients were clinically assessed at baseline and after 4, 8, and 12 weeks of treatment and 4 weeks after treatment.
The functional properties of the stratum corneum (SC) were determined before treatment, 12 weeks, and follow-up phase by high-frequency conductance and transepidermal water loss (TEWL).
Results.
At the end of the trial, the mean reduction of the lesions from baseline was statistically significant for 10% LA (66%) and 5% SA (52%).
During the treatment, higher conductance values were found on both group and this improvement was maintained until the follow up period.
No significant differences in transepidermal water loss were observed after treatment.
The adverse effects were limited to mild irritation localized on the skin without systemic side effect.
Conclusion.
The study demonstrated that 10% LA and 5% SA are beneficial to treat KP with the significantly clearance and marked improvement as by instrumental evaluation.
American Psychological Association (APA)
Kootiratrakarn, Tanawatt& Kampirapap, Kowit& Chunhasewee, Chakkrapong. 2015. Epidermal Permeability Barrier in the Treatment of Keratosis Pilaris. Dermatology Research and Practice،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061096
Modern Language Association (MLA)
Kootiratrakarn, Tanawatt…[et al.]. Epidermal Permeability Barrier in the Treatment of Keratosis Pilaris. Dermatology Research and Practice No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1061096
American Medical Association (AMA)
Kootiratrakarn, Tanawatt& Kampirapap, Kowit& Chunhasewee, Chakkrapong. Epidermal Permeability Barrier in the Treatment of Keratosis Pilaris. Dermatology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061096