No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects
Joint Authors
Forero, Diego
González-Giraldo, Yeimy
Camargo, Andrés
López-León, Sandra
Source
Depression Research and Treatment
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Major depressive disorder (MDD) is the second cause of years lived with disability around the world.
A large number of studies have been carried out to identify genetic risk factors for MDD and related endophenotypes, mainly in populations of European and Asian descent, with conflicting results.
The main aim of the current study was to analyze the possible association of five candidate genes and depressive symptoms in a Colombian sample of healthy subjects.
Methods and Materials.
The Spanish adaptation of the Hospital Anxiety and Depression Scale (HADS) was applied to one hundred eighty-eight healthy Colombian subjects.
Five functional polymorphisms were genotyped using PCR-based assays: BDNF-Val66Met (rs6265), COMT-Val158Met (rs4680), SLC6A4-HTTLPR (rs4795541), MAOA-uVNTR, and SLC6A3-VNTR (rs28363170).
Result.
We did not find significant associations with scores of depressive symptoms, derived from the HADS, for any of the five candidate genes (nominal p values >0.05).
In addition, we did not find evidence of significant gene-gene interactions.
Conclusion.
This work is one of the first studies of candidate genes for depressive symptoms in a Latin American sample.
Study of additional genetic and epigenetic variants, taking into account other pathophysiological theories, will help to identify novel candidates for MDD in populations around the world.
American Psychological Association (APA)
González-Giraldo, Yeimy& Camargo, Andrés& López-León, Sandra& Forero, Diego. 2015. No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects. Depression Research and Treatment،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061118
Modern Language Association (MLA)
González-Giraldo, Yeimy…[et al.]. No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects. Depression Research and Treatment No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1061118
American Medical Association (AMA)
González-Giraldo, Yeimy& Camargo, Andrés& López-León, Sandra& Forero, Diego. No Association of BDNF, COMT, MAOA, SLC6A3, and SLC6A4 Genes and Depressive Symptoms in a Sample of Healthy Colombian Subjects. Depression Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1061118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061118