Wenxin Keli versus Sotalol for Paroxysmal Atrial Fibrillation Caused by Hyperthyroidism: A Prospective, Open Label, and Randomized Study
Joint Authors
Meng, Zhaowei
Tan, Jian
He, Qing
Zhu, Mei
Li, Xue
Zhang, Jianping
Jia, Qiang
Wang, Shen
Zhang, Guizhi
Zheng, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We aimed to compare effectiveness of Wenxin Keli (WK) and sotalol in assisting sinus rhythm (SR) restoration from paroxysmal atrial fibrillation (PAF) caused by hyperthyroidism, as well as in maintaining SR.
We randomly prescribed WK (18 g tid) or sotalol (80 mg bid) to 91 or 89 patients.
Since it was not ethical not to give patients antiarrhythmia drugs, no control group was set.
Antithyroid drugs were given to 90 patients (45 in WK group, 45 in sotalol group); 131I was given to 90 patients (46 in WK group, 44 in sotalol group).
Three months later, SR was obtained in 83/91 or 80/89 cases from WK or sotalol groups (P=0.762).
By another analysis, SR was obtained in 86/90 or 77/90 cases from 131I or ATD groups (P=0.022).
Then, we randomly assigned the successfully SR-reverted patients into three groups: WK, sotalol, and control (no antiarrhythmia drug was given) groups.
After twelve-month follow-up, PAF recurrence happened in 1/54, 2/54, and 9/55 cases, respectively.
Log-Rank test showed significant higher PAF recurrent rate in control patients than either treatment (P=0.06).
We demonstrated the same efficacies of WK and sotalol to assist SR reversion from hyperthyroidism-caused PAF.
We also showed that either drug could maintain SR in such patients.
American Psychological Association (APA)
Meng, Zhaowei& Tan, Jian& He, Qing& Zhu, Mei& Li, Xue& Zhang, Jianping…[et al.]. 2015. Wenxin Keli versus Sotalol for Paroxysmal Atrial Fibrillation Caused by Hyperthyroidism: A Prospective, Open Label, and Randomized Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061134
Modern Language Association (MLA)
Meng, Zhaowei…[et al.]. Wenxin Keli versus Sotalol for Paroxysmal Atrial Fibrillation Caused by Hyperthyroidism: A Prospective, Open Label, and Randomized Study. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061134
American Medical Association (AMA)
Meng, Zhaowei& Tan, Jian& He, Qing& Zhu, Mei& Li, Xue& Zhang, Jianping…[et al.]. Wenxin Keli versus Sotalol for Paroxysmal Atrial Fibrillation Caused by Hyperthyroidism: A Prospective, Open Label, and Randomized Study. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061134