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The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
Joint Authors
Brito, Gerly Anne de Castro
Chaves, Mariana H.
Marinho-Filho, José Delano Barreto
Carvalho, Karine Maria Martins Bezerra
de Melo, Tiago Sousa
Araújo, Ana Jérsia
Quetz, Josiane da Silva
da Cunha, Maria do Perpétuo Socorro Saldanha
de Melo, Karina Moura
da Silva, Armenio Andre de Carvalho Almeida
Tomé, Adriana Rocha
Havt, Alexandre
Fonseca, Said Gonçalves da Cruz
Rao, Vietla Satyanarayana
Santos, Flávia Almeida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolic disorders.
The present study investigated the antiobesity properties of resin from Protium heptaphyllum (RPH) and the possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks.
Mice treated with RPH showed decreases in body weight, net energy intake, abdominal fat accumulation, plasma glucose, amylase, lipase, triglycerides, and total cholesterol relative to their respective controls, which were RPH unfed.
Additionally, RPH treatment, while significantly elevating the plasma level of ghrelin hormone, decreased the levels of insulin, leptin, and resistin.
Besides, HFD-induced increases in plasma levels of proinflammatory mediators TNF-α, IL-6, and MCP-1 were significantly lowered by RPH.
Furthermore, in vitro studies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50 μg/mL.
These findings suggest that the antiobese potential of RPH is largely due to its modulatory effects on various hormonal and enzymatic secretions related to fat and carbohydrate metabolism and to the regulation of obesity-associated inflammation.
American Psychological Association (APA)
Carvalho, Karine Maria Martins Bezerra& Marinho-Filho, José Delano Barreto& de Melo, Tiago Sousa& Araújo, Ana Jérsia& Quetz, Josiane da Silva& da Cunha, Maria do Perpétuo Socorro Saldanha…[et al.]. 2015. The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061144
Modern Language Association (MLA)
Carvalho, Karine Maria Martins Bezerra…[et al.]. The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061144
American Medical Association (AMA)
Carvalho, Karine Maria Martins Bezerra& Marinho-Filho, José Delano Barreto& de Melo, Tiago Sousa& Araújo, Ana Jérsia& Quetz, Josiane da Silva& da Cunha, Maria do Perpétuo Socorro Saldanha…[et al.]. The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061144