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Effect of Powdered Shells of the Snail Megalobulimus lopesi on Secondary-Intention Wound Healing in an Animal Model
Joint Authors
Andrade, Paulo Henrique Muleta
Schmidt Rondon, Eric
Carollo, Carlos Alexandre
Rodrigues Macedo, Maria Lígia
Viana, Luiz Henrique
Schiaveto de Souza, Albert
Turatti Oliveira, Carolina
Cepa Matos, Maria de Fatima
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Topical administration of powdered shells of the land snail Megalobulimus lopesi was evaluated in Wistar rats for their healing activity in an excision wound model.
The animals were distributed into three groups—G1 (control): no therapeutic intervention; G2 (vehicle controls): Lanette cream once daily; G3 (experimental animals): treated with powdered shells.
Variables investigated were: wound area contraction, angiogenic activity, morphometric data, leukocytic inflammatory infiltrate, and total leukocyte count in peripheral blood.
Thermogravimetric analysis and quantification and characterization of powdered shell proteins were also performed.
Wound area on days 3, 7, and 14 was smaller in G3, besides presenting wound closure on day 21 for all these animals.
Topical administration of the powdered shells also led to an increased number of vessels at the wound site, higher leukocyte counts in peripheral blood, and increased leukocytic inflammatory infiltrate.
The results lend support to the southern Brazilian folk use of M.
lopesi powdered shells, as shown by the enhanced secondary-intention healing achieved with their topical administration to wounds in rats.
Topical administration caused inflammatory response modulation, crucial to accelerating the healing process, the chronification of which increases the risks of wound contamination by opportunistic pathogens.
American Psychological Association (APA)
Andrade, Paulo Henrique Muleta& Schmidt Rondon, Eric& Carollo, Carlos Alexandre& Rodrigues Macedo, Maria Lígia& Viana, Luiz Henrique& Schiaveto de Souza, Albert…[et al.]. 2015. Effect of Powdered Shells of the Snail Megalobulimus lopesi on Secondary-Intention Wound Healing in an Animal Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061148
Modern Language Association (MLA)
Andrade, Paulo Henrique Muleta…[et al.]. Effect of Powdered Shells of the Snail Megalobulimus lopesi on Secondary-Intention Wound Healing in an Animal Model. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061148
American Medical Association (AMA)
Andrade, Paulo Henrique Muleta& Schmidt Rondon, Eric& Carollo, Carlos Alexandre& Rodrigues Macedo, Maria Lígia& Viana, Luiz Henrique& Schiaveto de Souza, Albert…[et al.]. Effect of Powdered Shells of the Snail Megalobulimus lopesi on Secondary-Intention Wound Healing in an Animal Model. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061148