Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro
Joint Authors
Chua, Eng-Guan
Verbrugghe, Phebe
Perkins, Timothy T.
Tay, Chin-Yen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Fucoidans are complex sulphated polysaccharides derived from abundant and edible marine algae.
Helicobacter pylori is a stomach pathogen that persists in the hostile milieu of the human stomach unless treated with antibiotics.
This study aims to provide preliminary data to determine, in vitro, if fucoidans can inhibit the growth of H.
pylori and its ability to adhere to gastric epithelial cells (AGS).
We analysed the activity of three different fucoidan preparations (Fucus A, Fucus B, and Undaria extracts).
Bacterial growth was not arrested or inhibited by the fucoidan preparations supplemented into culture media.
All fucoidans, when supplemented into tissue culture media at 1000 µg mL−1, were toxic to AGS cells and reduced the viable cell count significantly.
Fucoidan preparations at 100 µg mL−1 were shown to significantly reduce the number of adherent H.
pylori.
These in vitro findings provide the basis for further studies on the clinical use of sulphated polysaccharides as complementary therapeutic agents.
American Psychological Association (APA)
Chua, Eng-Guan& Verbrugghe, Phebe& Perkins, Timothy T.& Tay, Chin-Yen. 2015. Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061149
Modern Language Association (MLA)
Chua, Eng-Guan…[et al.]. Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1061149
American Medical Association (AMA)
Chua, Eng-Guan& Verbrugghe, Phebe& Perkins, Timothy T.& Tay, Chin-Yen. Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1061149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061149