The Synergistic Beneficial Effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a Mouse Model of Dementia
Joint Authors
Wang, Zhenzhong
Xiao, Wei
Fang, Xianying
Jiang, Yan
Ji, Hui
Zhao, Linguo
Ding, Gang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study reports the combination of Ginkgo flavonoid (GF) and Coriolus versicolor polysaccharide (CVP) in the prevention and treatment of a mouse model of Alzheimer’s disease (AD).
GF is a traditional health product, and CVP is the main active ingredient of the medicinal fungus Coriolus versicolor.
The Morris water maze test, the Y maze, and the step-through test showed that the combinational use of CVP and GF synergistically improved memory in a mouse model of AD.
Based on H&E staining analysis, the combination of CVP and GF decreased the severity of the pathological findings in the brain.
Given that the expression of IL-1β, IL-6, and TNF-α was downregulated, the inflammation response in AD mice was considered to be inhibited.
The downregulation of GFAP further demonstrated that inflammation was reduced in the brain of AD mice following treatment.
Moreover, the expression levels of superoxide dismutase (SOD) and catalase (CAT) were elevated in the brains of treated mice, indicating that oxidation levels were reduced upon the combination treatment.
Our results provide new insights into the efficient utilization of traditional medicine for preventing dementia.
American Psychological Association (APA)
Fang, Xianying& Jiang, Yan& Ji, Hui& Zhao, Linguo& Xiao, Wei& Wang, Zhenzhong…[et al.]. 2015. The Synergistic Beneficial Effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a Mouse Model of Dementia. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061155
Modern Language Association (MLA)
Fang, Xianying…[et al.]. The Synergistic Beneficial Effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a Mouse Model of Dementia. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061155
American Medical Association (AMA)
Fang, Xianying& Jiang, Yan& Ji, Hui& Zhao, Linguo& Xiao, Wei& Wang, Zhenzhong…[et al.]. The Synergistic Beneficial Effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a Mouse Model of Dementia. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061155