Protective Effect of Tetrandrine on Sodium Taurocholate-Induced Severe Acute Pancreatitis
Joint Authors
Xing, Hui-Jie
Wu, Xian-lin
Li, Jie-xing
Li, Zhen-dong
Liu, Da-sheng
Liu, Kang-li
Duan, Hong-yan
Luo, Yu-hong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tet is a type of alkaloid extracted from Stephania tetrandra, and it has recently been demonstrated that Tet can protect against inflammation and free radical injury and inhibit the release of inflammatory mediators.
The present study was designed to observe the protective effect of Tet on sodium taurocholate-induced severe acute pancreatitis (SAP).
The rat model of SAP was induced by retrograde bile duct injection of sodium taurocholate and then treated with Verapamil and Tet.
The results showed that Tet can reduce NF-κB activation in pancreas issue, inhibit the SAP cascade, and improve SAP through inducing pancreas acinar cell apoptosis and stabilizing intracellular calcium in the pancreas, thus mitigating the damage to the pancreas.
Our study revealed that Tet may reduce systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndromes (MODS) to protect against damage, and these roles may be mediated through the NF-κB pathway to improve the proinflammatory/anti-inflammatory imbalance.
American Psychological Association (APA)
Wu, Xian-lin& Li, Jie-xing& Li, Zhen-dong& Liu, Da-sheng& Xing, Hui-Jie& Liu, Kang-li…[et al.]. 2015. Protective Effect of Tetrandrine on Sodium Taurocholate-Induced Severe Acute Pancreatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061156
Modern Language Association (MLA)
Wu, Xian-lin…[et al.]. Protective Effect of Tetrandrine on Sodium Taurocholate-Induced Severe Acute Pancreatitis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061156
American Medical Association (AMA)
Wu, Xian-lin& Li, Jie-xing& Li, Zhen-dong& Liu, Da-sheng& Xing, Hui-Jie& Liu, Kang-li…[et al.]. Protective Effect of Tetrandrine on Sodium Taurocholate-Induced Severe Acute Pancreatitis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061156