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Aquapuncture Using Stem Cell Therapy to Treat Mdx Mice
Joint Authors
Esper, Greyson Vitor Zanatta
Pignatari, Graciela Conceição
Rodrigues, Marcio Nogueira
Bertagnon, Heloisa Godoi
Fernandes, Isabella Rodrigues
Nascimento, Nanci
Tabosa, Angela Maria Florencio
Beltrão-Braga, Patrícia Cristina Baleeiro
Miglino, Maria Angelica
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Duchenne muscular dystrophy (DMD) occurs due to genetic mutations that lead to absence or decrease of dystrophin protein generating progressive muscle degeneration.
Cell therapy using mesenchymal stem cell (MSC) has been described as a treatment to DMD.
In this work, MSC derived from deciduous teeth, called stem cells from human exfoliated deciduous teeth (SHED), were injected in acupoint as an alternative therapy to minimize muscle degeneration in twenty-two mdx mice.
The treatment occurred three times with intervals of 21 days, and animals were analyzed four times: seven days prior treatment (T-7); 10 days after first treatment (T10); 10 days after second treatment (T31); and 10 days after third treatment (T52).
Animals were evaluated by wire test for estimate strength and blood was collected to perform a creatinine phosphokinase analysis.
After euthanasia, cranial tibial muscles were collected and submitted to histological and immunohistochemistry analyses.
Treated groups presented improvement of strength and reduced creatinine phosphokinase levels.
Also, a slight dystrophin increase was observed in tibial cranial muscle when aquapuncture was associated SHED.
All therapies have minimized muscle degeneration, but the association of aquapuncture with SHED appears to have better effect, reducing muscle damage, suggesting a therapeutic value.
American Psychological Association (APA)
Esper, Greyson Vitor Zanatta& Pignatari, Graciela Conceição& Rodrigues, Marcio Nogueira& Bertagnon, Heloisa Godoi& Fernandes, Isabella Rodrigues& Nascimento, Nanci…[et al.]. 2015. Aquapuncture Using Stem Cell Therapy to Treat Mdx Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061160
Modern Language Association (MLA)
Esper, Greyson Vitor Zanatta…[et al.]. Aquapuncture Using Stem Cell Therapy to Treat Mdx Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061160
American Medical Association (AMA)
Esper, Greyson Vitor Zanatta& Pignatari, Graciela Conceição& Rodrigues, Marcio Nogueira& Bertagnon, Heloisa Godoi& Fernandes, Isabella Rodrigues& Nascimento, Nanci…[et al.]. Aquapuncture Using Stem Cell Therapy to Treat Mdx Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061160