Agaricoglycerides Protect against Hepatic IschemiaReperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB

Abstract EN

We have investigated the effects of agaricoglycerides (AG) in a mouse model of hepatic I/R injury.

I/R triggered increases/changes in markers of liver injury, hepatic oxidative stress, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nuclear factor κB (NF-κB).

AG significantly reduced the extent of liver inflammation and oxidative stress and also attenuated the NF-κB activation as well as TNF-α and IL-1β production.

Our results indicate that AG may represent a novel protective strategy against I/R-induced injury and inflammatory diseases.