Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation
Joint Authors
Adem, Abdu
Ojha, Shreesh
Sheikh, Azimullah
Mohanraj, Rajesh
Sharma, Charu
Yasin, Javed
Arya, Dharmveer S.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study was aimed at investigating the cardioprotective activity of thymoquinone (TMQ), an active principle of the herb, Nigella sativa, which is used for the management of various diseases.
The present study examined the cardioprotective effect of TMQ in isoproterenol- (ISP-) induced myocardial infarction in rats.
Myocardial infarction was induced by two subcutaneous injections of ISP (85 mg/kg) at an interval of 24 hr.
TMQ (20 mg/kg) was administered orally for 21 days.
ISP-treated rats showed depletion of antioxidants and marker enzymes from myocardium along with lipid peroxidation and enhanced levels of proinflammatory cytokines.
ISP also induced histopathological alterations in myocardium.
Treatment with TMQ prevented the depletion of endogenous antioxidants and myocyte injury marker enzymes and inhibited lipid peroxidation as well as reducing the levels of proinflammatory cytokines.
TMQ pretreatment also reduced myonecrosis, edema, and infiltration of inflammatory cells and showed preservation of cardiomyocytes histoarchitecture.
The present study results demonstrate that TMQ exerts cardioprotective effect by mitigating oxidative stress, augmenting endogenous antioxidants, and maintaining structural integrity.
The results of the present study indicate that TMQ may serve as an excellent agent alone or as adjuvant to prevent the onset and progression of myocardial injury.
American Psychological Association (APA)
Ojha, Shreesh& Sheikh, Azimullah& Mohanraj, Rajesh& Sharma, Charu& Yasin, Javed& Arya, Dharmveer S.…[et al.]. 2015. Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061170
Modern Language Association (MLA)
Ojha, Shreesh…[et al.]. Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061170
American Medical Association (AMA)
Ojha, Shreesh& Sheikh, Azimullah& Mohanraj, Rajesh& Sharma, Charu& Yasin, Javed& Arya, Dharmveer S.…[et al.]. Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061170