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Diene Valepotriates from Valeriana glechomifolia Prevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice
Joint Authors
Müller, Liz G.
Borsoi, Milene
Stolz, Eveline D.
Herzfeldt, Vivian
Viana, Alice F.
Ravazzolo, Ana Paula
Rates, Stela Maris K.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Valeriana glechomifolia, a native species from southern Brazil, presents antidepressant-like activity and diene valepotriates (VAL) contribute to the pharmacological properties of the genus.
It is known that depression can develop on an inflammation background in vulnerable patients and antidepressants present anti-inflammatory properties.
We investigated the effects of VAL (10 mg/kg, p.o.) on sickness and depressive-like behaviors as well as proinflammatory cytokines (IL-1β and TNF-α) and BDNF expression in the cortex of mice exposed to a 5 min swimming session (as a stressful stimulus) 30 min before the E.
coli LPS injection (600 µg/kg, i.p.).
The forced swim + LPS induced sickness and depressive-like behaviors, increased the cortical expression of IL-1β and TNF-α, and decreased BDNF expression.
VAL was orally administered to mice 1 h before (pretreatment) or 5 h after (posttreatment) E.
coli LPS injection.
The pretreatment with VAL restored the behavioral alterations and the expression of cortical proinflammatory cytokines in LPS-injected animals but had no effects on BDNF expression, while the posttreatment rescued only behavioral alterations.
Our results demonstrate for the first time the positive effects of VAL in an experimental model of depression associated with inflammation, providing new data on the range of action of these molecules.
American Psychological Association (APA)
Müller, Liz G.& Borsoi, Milene& Stolz, Eveline D.& Herzfeldt, Vivian& Viana, Alice F.& Ravazzolo, Ana Paula…[et al.]. 2015. Diene Valepotriates from Valeriana glechomifolia Prevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061175
Modern Language Association (MLA)
Müller, Liz G.…[et al.]. Diene Valepotriates from Valeriana glechomifolia Prevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061175
American Medical Association (AMA)
Müller, Liz G.& Borsoi, Milene& Stolz, Eveline D.& Herzfeldt, Vivian& Viana, Alice F.& Ravazzolo, Ana Paula…[et al.]. Diene Valepotriates from Valeriana glechomifolia Prevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061175