Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson’s Disease
Joint Authors
Neves, Kelly Rose
Bitu Pinto, Natália
da Silva Alexandre, Bruno
Silva, Aline Holanda
Viana, Glauce Socorro de Barros
Leal, Luzia Kalyne Almeida Moreira
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Camellia sinensis (green tea) is largely consumed, mainly in Asia.
It possesses several biological effects such as antioxidant and anti-inflammatory properties.
The objectives were to investigate the neuroprotective actions of the standardized extract (CS), epicatechin (EC) and epigallocatechin gallate (EGCG), on a model of Parkinson’s disease.
Male Wistar rats were divided into SO (sham-operated controls), untreated 6-OHDA-lesioned and 6-OHDA-lesioned treated for 2 weeks with CS (25, 50, or 100 mg/kg), EC (10 mg/kg), or EGCG (10 mg/kg) groups.
One hour after the last administration, animals were submitted to behavioral tests and euthanized and their striata and hippocampi were dissected for neurochemical (DA, DOPAC, and HVA) and antioxidant activity determinations, as well as immunohistochemistry evaluations (TH, COX-2, and iNOS).
The results showed that CS and catechins reverted behavioral changes, indicating neuroprotection manifested as decreased rotational behavior, increased locomotor activity, antidepressive effects, and improvement of cognitive dysfunction, as compared to the untreated 6-OHDA-lesioned group.
Besides, CS, EP, and EGCG reversed the striatal oxidative stress and immunohistochemistry alterations.
These results show that the neuroprotective effects of CS and its catechins are probably and in great part due to its powerful antioxidant and anti-inflammatory properties, pointing out their potential for the prevention and treatment of PD.
American Psychological Association (APA)
Bitu Pinto, Natália& da Silva Alexandre, Bruno& Neves, Kelly Rose& Silva, Aline Holanda& Leal, Luzia Kalyne Almeida Moreira& Viana, Glauce Socorro de Barros. 2015. Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061192
Modern Language Association (MLA)
Bitu Pinto, Natália…[et al.]. Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061192
American Medical Association (AMA)
Bitu Pinto, Natália& da Silva Alexandre, Bruno& Neves, Kelly Rose& Silva, Aline Holanda& Leal, Luzia Kalyne Almeida Moreira& Viana, Glauce Socorro de Barros. Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061192