![](/images/graphics-bg.png)
Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract
Joint Authors
Mroueh, Mohamad
Tenkerian, Clara
El-Sibai, Mirvat
Daher, Costantine F.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tragopogon porrifolius (Asteraceae), commonly referred to as white salsify, is an edible herb used in Lebanese folk medicine to treat cancer and liver dysfunction.
In this study, we investigated the antioxidant activity of Tragopogon porrifolius methanolic extract, both in vitro and in vivo, in addition to its hepatoprotective and anticancer activities.
Total phenolic and flavonoid contents were measured and found to be 37.0±1.40 mg GAE/g and 16.6±0.42 mg QE/g dry weight, respectively.
In vitro antioxidant assays revealed an FRAP value of 659±13.8 µmol Fe2+/g of extract and DPPH IC50 value 15.2 µg/mL.
In rats subjected to CCl4-induced hepatotoxicity, significant increase in CAT, SOD, and GST levels was detected.
The highest dose of the extract (250 mg/kg) recorded a fold increase of 1.68 for SOD, 2.49 for GST, and 3.2 for CAT.
The extract also showed substantial decrease in AST (57%), ALT (56%), and LDH (65%) levels.
Additionally, the extract caused a dose-dependent decrease in cell viability and proliferation.
In conclusion, the methanolic extract of T.
porrifolius displayed a relatively high antioxidant activity both in vitro and in vivo as well as hepatoprotective potential against liver toxicity in rats and anticancer effect on MDA-MB-231 and Caco-2 cells.
American Psychological Association (APA)
Tenkerian, Clara& El-Sibai, Mirvat& Daher, Costantine F.& Mroueh, Mohamad. 2015. Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061193
Modern Language Association (MLA)
Tenkerian, Clara…[et al.]. Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061193
American Medical Association (AMA)
Tenkerian, Clara& El-Sibai, Mirvat& Daher, Costantine F.& Mroueh, Mohamad. Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061193