Protective Effects of Total Saponins of Panax Notoginseng on Steroid-Induced Avascular Necrosis of the Femoral Head In Vivo and In Vitro
Joint Authors
Yuan, Heng-feng
Pan, Jian-feng
Li, Shuo
Guo, Chang-an
Liu, Shu-hao
Yan, Zuo-qin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This research was designed to investigate the protective effects of TSPN on steroid-induced avascular necrosis of the femoral head (ANFH) and the likely mechanisms of those effects.
As an in vivo study, TSPN was shown to be protective against steroid-induced ANFH due to the upregulation of VEGF-A.
Furthermore, TSPN attenuated the apoptosis of osteocytes and reduced the expression of Caspase-3 relative to the model group.
As an in vitro study, TSPN exerted a concentration-dependent protective effect against apoptosis in MC3T3-E1 cells.
Moreover, TSPN (at a dose of 100 μg/mL) significantly reversed the dexamethasone-induced augmentation of Caspase-3 expression and activity.
Therefore, our study demonstrated that TSPN had a protective effect against steroid-induced ANFH that was related to the upregulation of VEGF-A and the inhibition of apoptosis and Caspase-3 activation.
American Psychological Association (APA)
Yuan, Heng-feng& Pan, Jian-feng& Li, Shuo& Guo, Chang-an& Liu, Shu-hao& Yan, Zuo-qin. 2015. Protective Effects of Total Saponins of Panax Notoginseng on Steroid-Induced Avascular Necrosis of the Femoral Head In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061198
Modern Language Association (MLA)
Yuan, Heng-feng…[et al.]. Protective Effects of Total Saponins of Panax Notoginseng on Steroid-Induced Avascular Necrosis of the Femoral Head In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061198
American Medical Association (AMA)
Yuan, Heng-feng& Pan, Jian-feng& Li, Shuo& Guo, Chang-an& Liu, Shu-hao& Yan, Zuo-qin. Protective Effects of Total Saponins of Panax Notoginseng on Steroid-Induced Avascular Necrosis of the Femoral Head In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061198